High altitude medicine in China in the 21st century: opportunities and challenges

详细信息    查看全文

• 作者：Lan Huang
• 关键词：High altitude ; High altitude disease ; Acute mountain sickness ; Lake Louise system
• 刊名：Military Medical Research
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：1
• 期：1
• 全文大小：251KB
• 参考文献：1.Wu TY, Chen GJ, Li GL, Wang XZ, Zhang QM: Hypertension and coronary heart disease at high altitude in qinghai province (author鈥檚 transl). Zhonghua Xin Xue Guan Bing Za Zhi 1979, 7:161鈥?63.PubMed
  2.Zhang SF, Zhang DH, Liu HP, Gao W, Luo XH, Wu JY, Lin SX, Liu CL, Zhang XY, Chen TD: Criteria suitable for diagnosis of acute respiratory distress syndrome/multiple organ dysfunction syndrome at moderately high altitude area. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2005, 17:217鈥?22.PubMed
  3.Wu TY: Editorial of the creteria of diagonosis of high altitude disease in China. High Alt Mag 1993, 5:63鈥?8.
  4.Zhongyuan S, Xuehan N, Pengguo H, Shoucheng Z, Deming Z, Shengyue Y, Yan W, Zhaoshen D: Comparison of physiological responses to hypoxia at high altitudes between highlanders and lowlanders. Sheng Li Xue Bao 1979, 22:1455鈥?469.
  5.Ji F, Sharpley MS, Derbeneva O, Alves LS, Qian P, Wang Y, Chalkia D, Lvova M, Xu J, Yao W, Simon M, Platt J, Xu S, Angelin A, Davila A, Huang T, Wang PH, Chuang LM, Moore LG, Qian G, Wallace DC: Mitochondrial DNA variant associated with leber hereditary optic neuropathy and high-altitude tibetans. Proc Natl Acad Sci U S A 2012, 109:7391鈥?396. 10.1073/pnas.1202484109CrossRef PubMed Central PubMed
  6.Li Q, Bi HR, Zhang R, Zhu DL: Kv3.4 channel is involved in rat pulmonary vasoconstriction induced by 15-hydroxyeicosatetraenoic acid. Sheng Li Xue Bao 2006, 58:77鈥?2.PubMed
  7.Yi X, Liang Y, Huerta-Sanchez E, Jin X, Cuo ZX, Pool JE, Xu X, Jiang H, Vinckenbosch N, Korneliussen TS, Zheng H, Liu T, He W, Li K, Luo R, Nie X, Wu H, Zhao M, Cao H, Zou J, Shan Y, Li S, Yang Q, Asan Ni P, Tian G, Xu J, Liu X, Jiang T, Wu R, Zhou G, et al.: Sequencing of 50 human exomes reveals adaptation to high altitude. Science 2010, 329:75鈥?8. 10.1126/science.1190371CrossRef PubMed Central PubMed
  8.Long M, Huang L, Tian K, Yu S, Yu Y, Qin J: Relationship between autonomic nervous system function and acute mountain sickness. J Med Coll PLA 2008, 23:7.
  9.Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, Prchal JT, Ge R: Genetic evidence for high-altitude adaptation in Tibet. Science 2010, 329:72鈥?5. 10.1126/science.1189406CrossRef PubMed
  10.West JB: The qinghai-tibet railway. High Alt Med Biol 2008, 9:1鈥?.CrossRef PubMed
  11.Shi HS: Management of occupational hygiene security in qing-zang railway construction. Chin J Ind Hyg Occup Dis 2008, 26:670鈥?73.
  12.Song YH, Kong XH, Nan YM: Study on high altitude environment affecting on worker鈥檚 heart function during the constructing qinghai-xizang railway. Chin J Ind Hyg Occup Dis 2007, 25:487鈥?88.
  13.Ren Y, Fu Z, Shen W, Jiang P, He Y, Peng S, Wu Z, Cui B: Incidence of high altitude illnesses among unacclimatized persons who acutely ascended to tibet. High Alt Med Biol 2010, 11:39鈥?2. 10.1089/ham.2009.1049CrossRef PubMed
  14.The Lake Louise Consensus on the Definition of Altitude Illness: Hypoxia and mountain medicine. Burlington, Vermont: Queen City Printers; 1992.
  15.Third Ad Hoc Committee on High Altitude Illnesses of Chinese Medical Association: Consensus statement for the criteria for the denomination, classification and diagnosis of high altitude illnesses in china. Tibetan Med J 1996, 17:1鈥?.
  16.Koch RO, Burtscher M: Do we have a best practice for treating high altitude pulmonary edema? High Alt Med Biol 2008, 9:343鈥?44. 10.1089/ham.2008.1063CrossRef PubMed
  17.Dong JQ, Zhang JH, Qin J, Li QN, Huang W, Gao XB, Yu J, Chen GZ, Tang XG, Huang L: Anxiety correlates with somatic symptoms and sleep status at high altitudes. Physiol Behav 2013, 112鈥?13:23鈥?1.CrossRef PubMed
  18.Chen GZ, Qin J, Yu J, Gao XB, Dong JQ, Lu W, Bian SZ, Zeng Y, Huang L: Incidence of acute mountain sickness in young adults at 3200 meters: comparison of the lake louise scoring and chinese scoring systems. Genet Mol Res 2013, 12:6790鈥?801. 10.4238/2013.December.16.5CrossRef PubMed
  19.Bian SZ, Zhang JH, Gao XB, Li M, Yu J, Liu X, Dong JQ, Chen GZ, Huang L: Risk factors for high-altitude headache upon acute high-altitude exposure at 3700 m in young chinese men: a cohort study. J Headache Pain 2013, 14:35. 10.1186/1129-2377-14-35CrossRef PubMed Central PubMed
  
• 作者单位：Lan Huang (2)
  
  2. Department of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China
  
• 刊物类别：Emergency Medicine;
• 刊物主题：Emergency Medicine;
• 出版者：BioMed Central
• ISSN：2054-9369

文摘

China has the largest plateau, Qinghai-Tibet Plateau, where inhabited the most high altitude populations. Moreover, millions of people from plain areas come to the plateau for travel and work purposes and the number of the newcomers has been increasing every year. The hypoxic environment of plateau raised a series of related health issues in the new immigrants, so have created a special medical discipline - High Altitude Medicine. Over the past decades, researches on high altitude medicine have never being ceased in China, and lots of research findings have been reported. Application and practice of these achievements have greatly decreased the mobility and mortality of high-altitude diseases, however, there remained lots of questions to be elucidated. In view of this, the authors were granted a special project from the National Health and Family Planning Commission of China, and conducted a multi-center, prospective, on-scene high altitude medicine study for the acute mountain sickness. Some innovative findings were achieved, and the parameters for diagnosis and application conditions were proposed. Furthermore, the different diagnoses and treatment effects were compared, and a more standardized, reasonable scheme was drawn up. Regarding the unbalanced medical resources in the vast high altitude area, an application system for the public and the army has been established. In the 21st century, innovations in China and novel research approaches have provided great opportunities for the development of high altitude medicine. It is believed that the researchers in China are able to catch the opportunities and address the challenges. Keywords High altitude High altitude disease Acute mountain sickness Lake Louise system