Correction of compliance and resistance altered by endotracheal tube leaks and non-linear pressure/volume-relationships

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• 作者：Werner Nikischin and Malte Lange
• 关键词：Endotracheal tube leak ; Pulmonary function test ; Neonates ; Newborns ; Non ; linear pressure volume relationship
• 刊名：European Journal of Applied Physiology
• 出版年：2007
• 出版时间：February, 2007
• 年：2007
• 卷：99
• 期：3
• 页码：301-311
• 全文大小：305 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Physiology
  Occupational and Industrial Medicine
  Sports Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1439-6327

文摘

Measurements of lung compliance (C) and resistance (R) are influenced by endotracheal tube leaks (ETTL) as well as non-linear pressure/volume relationships (P/V relationship). To keep C and R reliable, we developed an algorithm to mathematically correct inspiratory and expiratory volume (V) and flow. In this study, a ventilated lung model for non-linear P/V relationship with adjustment of an increasing ETTL was studied. In addition, the recordings (airway pressure, flow, and volume) of 21 infants (median weight: 1,220 g, range: 640–2,160 g, with a median leak size of 32%, range: 24–56%) were investigated. C and R were calculated continuously from the recordings of flow, volume, and airway pressure over time according to the changing volume. A method especially developed for the analysis of non-linear pressure-volume-relationship (APVNL) was employed. C and R affected by leaks were corrected applying the newly developed mathematical algorithm and compared with measurements without leakage. C could be corrected up to a leak of 80% and R up to 55% leak at half tidal V for the model with non-linear P/V-R. C and R without leak and after leak correction did not differ significantly in all infants where the APVNL method was applied (P > 0.05).