Characterizing the insecticide resistance of Anopheles gambiae in Mali
详细信息 查看全文
- 作者：Moussa B. M. Cisse ; Chitan Keita ; Abdourhamane Dicko ; Dereje Dengela…
- 关键词：Anopheles gambiae ; Insecticide ; based malaria vector control ; Vector ; insecticide resistance ; Resistance monitoring ; Mali
- 刊名：Malaria Journal
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：14
- 期：1
- 全文大小：1,395 KB
- 刊物主题：Parasitology; Infectious Diseases; Tropical Medicine;
- 出版者：BioMed Central
- ISSN：1475-2875
文摘
Background The impact of indoor residual spraying (IRS) and long-lasting insecticide nets (LLINs), key components of the national malaria control strategy of Mali, is threatened by vector insecticide resistance. The objective of this study was to assess the level of insecticide resistance in Anopheles gambiae sensu lato populations from Mali against four classes of insecticide recommended for IRS: organochlorines (OCs), pyrethroids (PYs), carbamates (CAs) and organophosphates (OPs). Characterization of resistance was done in 13 sites across southern Mali and assessed presence and distribution of physiological mechanisms that included target-site modifications: knockdown resistance (kdr) and altered acetycholinesterase (AChE), and/or metabolic mechanisms: elevated esterases, glutathione S-transferases (GSTs), and monooxygenases.