Viral aetiology of acute respiratory infections among children and associated meteorological factors in southern China

详细信息    查看全文

• 作者：Binglin Cui (1)
  Dangui Zhang (2)
  Hui Pan (3)
  Fan Zhang (4)
  Jeremy Farrar (5)
  Frieda Law (6)
  H Rogier van Doorn (5)
  Beiyan Wu (1)
  William Ba-Thein (3) (7)
  
  1. Pediatric Department ; the First Affiliated Hospital of Shantou University Medical College ; Shantou ; Guangdong ; P.R. China
  2. The Research Center of Translational Medicine ; the Second Affiliated Hospital of Shantou University Medical College ; Shantou ; Guangdong ; P.R. China
  3. Shantou-Oxford Clinical Research Unit ; Shantou University Medical College ; Shantou ; Guangdong ; P.R. China
  4. Oncology Research Laboratory ; Cancer Hospital of Shantou University Medical College ; Shantou ; Guangdong ; P.R. China
  5. Oxford University Clinical Research Unit ; Hospital for Tropical Diseases ; Wellcome Trust Major Overseas Programme ; Ho Chi Minh City ; Viet Nam
  6. Consultant Office ; Shantou University Medical College ; Shantou ; Guangdong ; P.R. China
  7. Department of Microbiology and Immunology ; Shantou University Medical College ; Shantou ; Guangdong ; 515041 ; P.R. China
  
• 关键词：Virus ; Acute respiratory infection ; Meteorological factor ; Children ; China
• 刊名：BMC Infectious Diseases
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：1,020 KB
• 参考文献：1. Lin, YK, Chang, CK, Chang, SC, Chen, PS, Lin, C, Wang, YC (2013) Temperature, nitrogen dioxide, circulating respiratory viruses and acute upper respiratory infections among children in Taipei, Taiwan: a population-based study. Environ Res 120: pp. 109-118 CrossRef
  2. Feldman, RA, Kamath, KR, Rao, PS, Webb, JK (1969) Infection and disease in a group of South Indian families. I. Introduction, methods, definitions and general observations in a continuing study. Am J Epidemiol 89: pp. 364-374
  3. Monto, AS, Ullman, BM (1974) Acute respiratory illness in an American community. The Tecumseh study. JAMA 227: pp. 164-169 CrossRef
  4. Yusuf, S, Piedimonte, G, Auais, A, Demmler, G, Krishnan, S, Caeseele, P (2007) The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus. Epidemiol Infect 135: pp. 1077-1090 880600776X" target="_blank" title="It opens in new window">CrossRef
  5. Nair, H, Brooks, WA, Katz, M, Roca, A, Berkley, JA, Madhi, SA (2011) Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis. Lancet 378: pp. 1917-1930 CrossRef
  6. Kouni, S, Karakitsos, P, Chranioti, A, Theodoridou, M, Chrousos, G, Michos, A (2013) Evaluation of viral co-infections in hospitalized and non-hospitalized children with respiratory infections using microarrays. Clin Microbiol Infect 19: pp. 772-777 CrossRef
  7. Razanajatovo, NH, Richard, V, Hoffmann, J, Reynes, JM, Razafitrimo, GM, Randremanana, RV (2011) Viral etiology of influenza-like illnesses in Antananarivo, Madagascar, July 2008 to June 2009. PLoS One 6: pp. e17579 CrossRef
  8. Zou, L, Zhou, J, Li, H, Wu, J, Mo, Y, Chen, Q (2012) Human adenovirus infection in children with acute respiratory tract disease in Guangzhou. China APMIS 120: pp. 683-688 890.x" target="_blank" title="It opens in new window">CrossRef
  9. Debiaggi, M, Canducci, F, Ceresola, ER, Clementi, M (2012) The role of infections and coinfections with newly identified and emerging respiratory viruses in children. Virol J 9: pp. 247 86/1743-422X-9-247" target="_blank" title="It opens in new window">CrossRef
  10. Nascimento, MS, Souza, AV, Ferreira, AV, Rodrigues, JC, Abramovici, S, Silva Filho, LV (2010) High rate of viral identification and coinfections in infants with acute bronchiolitis. Clinics (Sao Paulo) 65: pp. 1133-1137 807-59322010001100014" target="_blank" title="It opens in new window">CrossRef
  11. Cilla, G, Onate, E, Perez-Yarza, EG, Montes, M, Vicente, D, Perez-Trallero, E (2008) Viruses in community-acquired pneumonia in children aged less than 3聽years old: High rate of viral coinfection. J Med Virol 80: pp. 1843-1849 CrossRef
  12. Esposito, S, Daleno, C, Prunotto, G, Scala, A, Tagliabue, C, Borzani, I (2013) Impact of viral infections in children with community-acquired pneumonia: results of a study of 17 respiratory viruses. Influenza Other Respi Viruses 7: pp. 18-26 CrossRef
  13. Peng, D, Zhao, D, Liu, J, Wang, X, Yang, K, Xicheng, H (2009) Multipathogen infections in hospitalized children with acute respiratory infections. Virol J 6: pp. 155 86/1743-422X-6-155" target="_blank" title="It opens in new window">CrossRef
  14. Chorazy, ML, Lebeck, MG, McCarthy, TA, Richter, SS, Torner, JC, Gray, GC (2013) Polymicrobial Acute Respiratory Infections in a Hospital-Based Pediatric Population. Pediatr Infect Dis J 32: pp. 460-466 828683ce" target="_blank" title="It opens in new window">CrossRef
  15. Jansen, RR, Schinkel, J, Koekkoek, S, Pajkrt, D, Beld, M, Jong, MD (2011) Development and evaluation of a four-tube real time multiplex PCR assay covering fourteen respiratory viruses, and comparison to its corresponding single target counterparts. J Clin Virol 51: pp. 179-185 CrossRef
  16. Lu, X, Holloway, B, Dare, RK, Kuypers, J, Yagi, S, Williams, JV (2008) Real-time reverse transcription-PCR assay for comprehensive detection of human rhinoviruses. J Clin Microbiol 46: pp. 533-539 8/JCM.01739-07" target="_blank" title="It opens in new window">CrossRef
  Clusters of acute respiratory illness associated with human enterovirus 68鈥揂sia, Europe, and United States 2008鈥?010. MMWR Morb Mortal Wkly Rep 60: pp. 1301-1304
  17. Jaramillo-Gutierrez, G, Benschop, KS, Claas, EC, Jong, AS, Loon, AM, Pas, SD (2013) September through October 2010 multi-centre study in the Netherlands examining laboratory ability to detect enterovirus 68, an emerging respiratory pathogen. J Virol Methods 190: pp. 53-62 CrossRef
  18. Huo, X, Qin, Y, Qi, X, Zu, R, Tang, F, Li, L (2012) Surveillance of 16 respiratory viruses in patients with influenza-like illness in Nanjing, China. J Med Virol 84: pp. 1980-1984 CrossRef
  19. Schlaudecker, EP, Heck, JP, Macintyre, ET, Martinez, R, Dodd, CN, McNeal, MM (2012) Etiology and seasonality of viral respiratory infections in rural honduran children. Pediatr Infect Dis J 31: pp. 1113-1118 826052eb" target="_blank" title="It opens in new window">CrossRef
  20. Vidaurreta, SM, Marcone, DN, Ellis, A, Ekstrom, J, Cukier, D, Videla, C (2011) [Acute viral respiratory infection in children under 5聽years: Epidemiological study in two centers in Buenos Aires, Argentina]. Arch Argent Pediatr 109: pp. 296-304 CrossRef
  21. Bharaj, P, Sullender, WM, Kabra, SK, Mani, K, Cherian, J, Tyagi, V (2009) Respiratory viral infections detected by multiplex PCR among pediatric patients with lower respiratory tract infections seen at an urban hospital in Delhi from 2005 to 2007. Virol J 6: pp. 89 86/1743-422X-6-89" target="_blank" title="It opens in new window">CrossRef
  22. Mathisen, M, Strand, TA, Sharma, BN, Chandyo, RK, Valentiner-Branth, P, Basnet, S (2009) RNA viruses in community-acquired childhood pneumonia in semi-urban Nepal; a cross-sectional study. BMC Med 7: pp. 35 86/1741-7015-7-35" target="_blank" title="It opens in new window">CrossRef
  23. Huguenin, A, Moutte, L, Renois, F, Leveque, N, Talmud, D, Abely, M (2012) Broad respiratory virus detection in infants hospitalized for bronchiolitis by use of a multiplex RT-PCR DNA microarray system. J Med Virol 84: pp. 979-985 CrossRef
  24. Stefanska, I, Romanowska, M, Donevski, S, Gawryluk, D, Brydak, LB (2013) Co-infections with influenza and other respiratory viruses. Adv Exp Med Biol 756: pp. 291-301 8-94-007-4549-0_36" target="_blank" title="It opens in new window">CrossRef
  25. Peng, J, Kong, W, Guo, D, Liu, M, Wang, Y, Zhu, H (2012) The epidemiology and etiology of influenza-like illness in Chinese children from 2008 to 2010. J Med Virol 84: pp. 672-678 CrossRef
  26. Paranhos-Baccala, G, Komurian-Pradel, F, Richard, N, Vernet, G, Lina, B, Floret, D (2008) Mixed respiratory virus infections. J Clin Virol 43: pp. 407-410 8.08.010" target="_blank" title="It opens in new window">CrossRef
  27. Ruohola, A, Waris, M, Allander, T, Ziegler, T, Heikkinen, T, Ruuskanen, O (2009) Viral etiology of common cold in children, Finland. Emerg Infect Dis 15: pp. 344-346 81468" target="_blank" title="It opens in new window">CrossRef
  28. Bergh, MR, Biesbroek, G, Rossen, JW, Steenhuijsen Piters, WA, Bosch, AA, Gils, EJ (2012) Associations between Pathogens in the Upper Respiratory Tract of Young Children: Interplay between Viruses and Bacteria. PLoS One 7: pp. e47711 CrossRef
  29. Jansen, RR, Wieringa, J, Koekkoek, SM, Visser, CE, Pajkrt, D, Molenkamp, R (2011) Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values. J Clin Microbiol 49: pp. 2631-2636 8/JCM.02094-10" target="_blank" title="It opens in new window">CrossRef
  30. Pierangeli, A, Gentile, M, Marco, P, Pagnotti, P, Scagnolari, C, Trombetti, S (2007) Detection and typing by molecular techniques of respiratory viruses in children hospitalized for acute respiratory infection in Rome, Italy. J Med Virol 79: pp. 463-468 832" target="_blank" title="It opens in new window">CrossRef
  31. Calvo, C, Garcia-Garcia, ML, Blanco, C, Vazquez, MC, Frias, ME, Perez-Brena, P (2008) Multiple simultaneous viral infections in infants with acute respiratory tract infections in Spain. J Clin Virol 42: pp. 268-272 8.03.012" target="_blank" title="It opens in new window">CrossRef
  32. Njouom, R, Yekwa, EL, Cappy, P, Vabret, A, Boisier, P, Rousset, D (2012) Viral etiology of influenza-like illnesses in cameroon, january-december 2009. J Infect Dis 206: pp. S29-S35 CrossRef
  33. Jennings, LC, Anderson, TP, Werno, AM, Beynon, KA, Murdoch, DR (2004) Viral etiology of acute respiratory tract infections in children presenting to hospital: role of polymerase chain reaction and demonstration of multiple infections. Pediatr Infect Dis J 23: pp. 1003-1007 8.04673.6c" target="_blank" title="It opens in new window">CrossRef
  34. Debyle, C, Bulkow, L, Miernyk, K, Chikoyak, L, Hummel, KB, Hennessy, T (2012) Comparison of nasopharyngeal flocked swabs and nasopharyngeal wash collection methods for respiratory virus detection in hospitalized children using real-time polymerase chain reaction. J Virol Methods 185: pp. 89-93 CrossRef
  35. Brunstein, JD, Cline, CL, McKinney, S, Thomas, E (2008) Evidence from multiplex molecular assays for complex multipathogen interactions in acute respiratory infections. J Clin Microbiol 46: pp. 97-102 8/JCM.01117-07" target="_blank" title="It opens in new window">CrossRef
  36. Prel, JB, Puppe, W, Grondahl, B, Knuf, M, Weigl, JA, Schaaff, F (2009) Are meteorological parameters associated with acute respiratory tract infections?. Clin Infect Dis 49: pp. 861-868 86/605435" target="_blank" title="It opens in new window">CrossRef
  37. Ji, W, Chen, ZR, Guo, HB, Wang, MJ, Yan, YD, Zhang, XL (2011) Characteristics and the prevalence of respiratory viruses and the correlation with climatic factors of hospitalized children in Suzhou children鈥檚 hospital. Zhonghua Yu Fang Yi Xue Za Zhi 45: pp. 205-210
  38. Chan, PK, Mok, HY, Lee, TC, Chu, IM, Lam, WY, Sung, JJ (2009) Seasonal influenza activity in Hong Kong and its association with meteorological variations. J Med Virol 81: pp. 1797-1806 CrossRef
  39. Tang, JW, Lai, FY, Nymadawa, P, Deng, YM, Ratnamohan, M, Petric, M (2010) Comparison of the incidence of influenza in relation to climate factors during 2000鈥?007 in five countries. J Med Virol 82: pp. 1958-1965 892" target="_blank" title="It opens in new window">CrossRef
  40. Khor, CS, Sam, IC, Hooi, PS, Quek, KF, Chan, YF (2012) Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27聽years. BMC Pediatr 12: pp. 32 86/1471-2431-12-32" target="_blank" title="It opens in new window">CrossRef
  41. Nascimento-Carvalho, CM, Cardoso, MR, Barral, A, Araujo-Neto, CA, Oliveira, JR, Sobral, LS (2010) Seasonal patterns of viral and bacterial infections among children hospitalized with community-acquired pneumonia in a tropical region. Scand J Infect Dis 42: pp. 839-844 8.2010.498020" target="_blank" title="It opens in new window">CrossRef
  42. Urashima, M, Shindo, N, Okabe, N (2003) A seasonal model to simulate influenza oscillation in Tokyo. Jpn J Infect Dis 56: pp. 43-47
  43. Chen, Z, Zhu, Y, Wang, Y, Zhou, W, Yan, Y, Zhu, C (2014) Association of meteorological factors with childhood viral acute respiratory infections in subtropical China: an analysis over 11聽years. Arch Virol 159: pp. 631-639 863-8" target="_blank" title="It opens in new window">CrossRef
  44. Chew, FT, Doraisingham, S, Ling, AE, Kumarasinghe, G, Lee, BW (1998) Seasonal trends of viral respiratory tract infections in the tropics. Epidemiol Infect 121: pp. 121-128 8898008905" target="_blank" title="It opens in new window">CrossRef
  45. Chan, PK, Sung, RY, Fung, KS, Hui, M, Chik, KW, Adeyemi-Doro, FA, Cheng, AF (1999) Epidemiology of respiratory syncytial virus infection among paediatric patients in Hong Kong: seasonality and disease impact. Epidemiol Infect 123: pp. 257-262 8899002824" target="_blank" title="It opens in new window">CrossRef
  46. Omer, SB, Sutanto, A, Sarwo, H, Linehan, M, Djelantik, IG, Mercer, D (2008) Climatic, temporal, and geographic characteristics of respiratory syncytial virus disease in a tropical island population. Epidemiol Infect 136: pp. 1319-1327 8807000015" target="_blank" title="It opens in new window">CrossRef
  47. Casanova, LM, Jeon, S, Rutala, WA, Weber, DJ, Sobsey, MD (2010) Effects of air temperature and relative humidity on coronavirus survival on surfaces. Appl Environ Microbiol 76: pp. 2712-2717 8/AEM.02291-09" target="_blank" title="It opens in new window">CrossRef
  48. Tang, JW, Lai, FY, Wong, F, Hon, KL (2010) Incidence of common respiratory viral infections related to climate factors in hospitalized children in Hong Kong. Epidemiol Infect 138: pp. 226-235 8809990410" target="_blank" title="It opens in new window">CrossRef
  49. Fang, LQ, Wang, LP, Vlas, SJ, Liang, S, Tong, SL, Li, YL (2012) Distribution and risk factors of 2009 pandemic influenza A (H1N1) in mainland China. Am J Epidemiol 175: pp. 890-897 CrossRef
  50. Landry, ML, Garner, R, Ferguson, D (2003) Comparison of the NucliSens Basic kit (Nucleic Acid Sequence-Based Amplification) and the Argene Biosoft Enterovirus Consensus Reverse Transcription-PCR assays for rapid detection of enterovirus RNA in clinical specimens. J Clin Microbiol 41: pp. 5006-5010 8/JCM.41.11.5006-5010.2003" target="_blank" title="It opens in new window">CrossRef
  51. Meijer A, Benschop KS, Donker GA, van der Avoort HG. Continued seasonal circulation of enterovirus D68 in the Netherlands, 2011鈥?014. Euro Surveill. 2014, 19(42). Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20935.
  52. Almeida, MB, Zerbinati, RM, Tateno, AF, Oliveira, CM, Romao, RM, Rodrigues, JC (2010) Rhinovirus C and respiratory exacerbations in children with cystic fibrosis. Emerg Infect Dis 16: pp. 996-999 CrossRef
  53. Martin, ET, Kuypers, J, Wald, A, Englund, JA (2012) Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children. Influenza Other Respi Viruses 6: pp. 71-77 CrossRef
  
• 刊物主题：Infectious Diseases; Parasitology; Medical Microbiology; Tropical Medicine; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2334

文摘

Background Acute respiratory infections (ARIs) are common in children and mostly caused by viruses, but the significance of the detection of multiple viruses in ARIs is unclear. This study investigated 14 respiratory viruses in ARIs among children and associated meteorological factors in Shantou, southern China. Methods Paired nasal/throat-flocked swabs collected from 1,074 children with ARIs, who visited outpatient walk-in clinics in a tertiary hospital between December 2010 and November 2011, were examined for fourteen respiratory viruses - influenza viruses (FluA, FluB), respiratory syncytial viruses (RSV A and B), human coronaviruses (hCoV: 229E, OC43, HKU1, NL63), human metapneumoviruses (hMPV A and B), parainfluenza viruses (PIV1-4), human rhinoviruses (HRV A, B, C), enteroviruses (EV), adenoviruses (ADV), human bocavirus (hBoV), and human parechoviruses (hPeV) - by multiplex real-time PCR. Results We identified at least one virus in 82.3% (884/1,074) and multiple viruses in 38.6% (415/1,074) of patients. EV and HRV were the most frequently detected single viruses (42.3%, 374/884 and 39.9%, 353/884 respectively) and co-detected pair (23.1%, 96/415). Overlapping seasonal trends of viruses were recorded over the year, with dual peaks for EV and single peaks for the others. By logistic regression analysis, EV was positively associated with the average temperature and humidity, hCoV, and PIV4, but negatively with HRV, PIV3, and hBoV. HRV was inversely associated with EV and PIV3. Conclusions This study reports high viral detection and co-detection rates in pediatric ARI cases mainly due to EV and HRV. Many viruses circulated throughout the year with similar seasonal trends in association with temperature, humidity, and wind velocity. Statistically significant associations were present among the viruses. Understanding the polyviral etiology and viral interactions in the cases with multiple viruses warrants further studies.