Recent progress in the discovery of inhibitors targeting coronavirus proteases

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• 作者：Haofeng Wang ; Song Xue ; Haitao Yang ; Cheng Chen
• 关键词：coronaviruses ; main protease ; protease inhibitors
• 刊名：Virologica Sinica
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：31
• 期：1
• 页码：24-30
• 全文大小：648 KB
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• 作者单位：Haofeng Wang (1)
  Song Xue (1)
  Haitao Yang (1)
  Cheng Chen (1)
  
  1. School of Life Sciences, Tianjin University, Tianjin, 300072, China
  
• 刊物主题：Virology; Medical Microbiology; Oncology; Biochemistry, general; Microbiology; Microbial Genetics and Genomics;
• 出版者：Springer Berlin Heidelberg
• ISSN：1995-820X

文摘

Coronaviruses (CoVs) can cause highly prevalent diseases in humans and animals. The fatal outbreak of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) highlights the threat posed by this unique virus subfamily. However, no specific drugs have been approved to treat CoV-associated diseases to date. The CoV proteases, which play pivotal roles in viral gene expression and replication through a highly complex cascade involving the proteolytic processing of replicase polyproteins, are attractive targets for drug design. This review summarizes the recent advances in biological and structural studies, together with the development of inhibitors targeting CoV proteases, particularly main proteases (Mpros), which could help develop effective treatments to prevent CoV infection. Keywords coronaviruses main protease protease inhibitors ORCID: 0000-0002-1875-3268