Development of dual responsive 5-fluorouracil loaded poly(N-vinylcaprolactam) based nanogels for targeted drug delivery applications

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• 作者：K. Sudhakar ; K. Madhusudana Rao ; M. C. S. Subha…
• 刊名：Polymer Science Series B
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：57
• 期：6
• 页码：638-644
• 全文大小：863 KB
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• 作者单位：K. Sudhakar (1)
  K. Madhusudana Rao (2)
  M. C. S. Subha (3)
  K. Chowdoji Rao (4)
  E. Rotimi Sadiku (1)
  
  1. Department of Polymer Technology, Tshwane University of Technology, CSIR Campus, Pretoria, South Africa
  2. Department of Polymer Science and Engineering, Pusan National University, Busan, 609-735, South Korea
  3. Department of Chemistry, Sri Krishnadevaraya University, Anantapur, A.P., India
  4. Department of Polymer Science and Technology, Sri Krishnadevaraya University, Anantapur, A.P., India
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Polymer Sciences
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1555-6123

文摘

Temperature and pH-responsive nanogels based on poly(N-vinylcaprolactam-co-2-dimethylaminoethylmethacrylate) synthesized by using a free radical emulsion polymerization procedure were developed and used for 5-Fluorouracil drug delivery. The formation of nanogel was confirmed by FTIR spectroscopy. TEM and DLS studies showed that the nanogels were spherical in shape and the average diameter of nanogels was about 100 nm. Further, 5-fluorouracil an anti-cancer drug was encapsulated into these nanogels via equilibrium swelling method. The encapsulation efficiency was dependent on network structure. The temperature/pH-dependent cumulative release properties were investigated for long-term delivery. The nanogels developed can be applied for tumor targeted drug delivery. The article is published in the original.