Whole-transcriptome analysis of mouse adipose tissue in response to short-term caloric restriction

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• 作者：Seung-Soo Kim ; Kyung-Mi Choi ; Soyoung Kim ; Taesun Park…
• 关键词：Caloric restriction strength ; Transcriptome ; Mice ; Transcription factor ; Adipose tissue
• 刊名：Molecular Genetics and Genomics
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：291
• 期：2
• 页码：831-847
• 全文大小：1,212 KB
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• 作者单位：Seung-Soo Kim (1)
  Kyung-Mi Choi (1)
  Soyoung Kim (2)
  Taesun Park (2)
  In-Cheol Cho (3)
  Jae-Won Lee (4)
  Cheol-Koo Lee (1)
  
  1. Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 136-701, Republic of Korea
  2. Department of Food and Nutrition, Yonsei University, Seoul, 120-749, Republic of Korea
  3. Subtropical Animal Station, National Institute of Animal Science, Jeju, 690-150, Republic of Korea
  4. Department of Statistics, Korea University, Seoul, 136-701, Republic of Korea
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Biochemistry
  Microbial Genetics and Genomics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1617-4623

文摘

Caloric restriction (CR) has been shown to extend the lifespan of many species by improving cellular function and organismal health. Additionally, fat reduction by CR may play an important role in lengthening lifespan and preventing severe age-related diseases. Interestingly, CR induced the greatest transcriptome change in the epididymal fat of mice in our study. In this transcriptome analysis, we identified and categorized 446 genes that correlated with CR level. We observed down-regulation of several signaling pathways, including insulin/insulin-like growth factor 1 (insulin/IGF-1), epidermal growth factor (EGF), transforming growth factor beta (TGF-β), and canonical wingless-type mouse mammary tumor virus integration site (Wnt). Many genes related to structural features, including extracellular matrix structure, cell adhesion, and the cytoskeleton, were down-regulated, with a strong correlation to the degree of CR. Furthermore, genes related to the cell cycle and adipogenesis were down-regulated. These biological processes are well-identified targets of insulin/IGF-1, EGF, TGF-β, and Wnt signaling. In contrast, genes involved in specific metabolic processes, including the tricarboxylic acid cycle and the electron transport chain were up-regulated. We performed in silico analysis of the promoter sequences of CR-responsive genes and identified two associated transcription factors, Paired-like homeodomain 2 (Pitx2) and Paired box gene 6 (Pax6). Our results suggest that strict regulation of signaling pathways is critical for creating the optimal energy homeostasis to extend lifespan.