Do not resuscitate orders and aging: Impact of multimorbidity on the decision-making process

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• 作者：L. De Decker (1)
  C. Annweiler (2) (3)
  C. Launay (2)
  B. Fantino (2)
  Olivier Beauchet (2) (4)
  
• 关键词：Do not resuscitate orders ; morbidities ; older adults
• 刊名：The journal of nutrition, health & aging
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：18
• 期：3
• 页码：330-335
• 全文大小：131 KB
• 参考文献：1. Shepardson LB, Youngner SJ, Speroff T et al. Variation in the use of do-notresuscitate orders in patients with stroke. Arch Intern Med. 1997; 157: 1841-847. doi.org/10.1001/archinte.1997.00440370081008" target="_blank" title="It opens in new window">CrossRef
  2. Wrenn K, Brody SL. Do-not-resuscitate orders in the emergency department. Am J Med. 1992; 92: 129-33. doi.org/10.1016/0002-9343(92)90102-H" target="_blank" title="It opens in new window">CrossRef
  3. Esteve A, Jimenez C, Perez R et al. Factors related to withholding life-sustaining treatment in hospitalized elders. J Nutr Health Aging. 2009; 13: 644-50. doi.org/10.1007/s12603-009-0176-9" target="_blank" title="It opens in new window">CrossRef
  4. Lo YT, Wang JJ, Liu LF al. Prevalence and related factors of do-not-resuscitate directives among nursing home residents in Taiwan. J Am Med Dir Assoc. 2010; 11: 436-42. doi.org/10.1016/j.jamda.2009.10.006" target="_blank" title="It opens in new window">CrossRef
  5. Chen JS, Wang HM, Wu SC et al. A population-based study on the prevalence and determinants of cardiopulmonary resuscitation in the last month of life for Taiwanese cancer decedents, 2001-2006. Resuscitation. 2009; 80: 1388-393. doi.org/10.1016/j.resuscitation.2009.08.015" target="_blank" title="It opens in new window">CrossRef
  6. Mark DH, Bahr J, Duthie EH et al. Characteristics of residents with do-notresuscitate orders in nursing homes. Arch Fam Med. 1995; 4: 463-67. doi.org/10.1001/archfami.4.5.463" target="_blank" title="It opens in new window">CrossRef
  7. Wenger NS, Pearson ML, Desmond KA et al. Epidemiology of do-not-resuscitate orders. Disparity by age, diagnosis, gender, race, and functional impairment. Arch Intern Med. 1995; 155: 2056-062. doi.org/10.1001/archinte.1995.00430190042006" target="_blank" title="It opens in new window">CrossRef
  8. Schwartz DA, Reilly P. The choice not to be resuscitated. J Am Geriatr Soc. 1986; 34: 807-11.
  9. Holtzman J, Pheley AM, Luri N. Changes in orders limiting care and the use of less aggressive care in a nursing home population. J Am Geriatr Soc. 1994; 42: 275-79.
  10. Gijsen R, Hoeymans N, Schellevis FG et al. Causes and consequences of comorbidity: a review. J Clin Epidemiol. 2001; 54: 661-74. doi.org/10.1016/S0895-4356(00)00363-2" target="_blank" title="It opens in new window">CrossRef
  11. Jackson EA, Yarzebski JL, Goldberg RJ et al. Do-not-resuscitate orders in patients hospitalized with acute myocardial infarction: the Worcester Heart Attack Study. Arch Intern Med. 2004; 164: 776-83. doi.org/10.1001/archinte.164.7.776" target="_blank" title="It opens in new window">CrossRef
  12. Bacchetta MD, Eachempati SR, Fins JJ et al. Factors influencing DNR decisionmaking in a surgical ICU. J Am Coll Surg. 2006; 202: 995-000. doi.org/10.1016/j.jamcollsurg.2006.02.027" target="_blank" title="It opens in new window">CrossRef
  13. Ismail A, Long J, Moiemen N et al. End of life decisions and care of the adult burn patient. Burns. 2011; 37: 288-93. doi.org/10.1016/j.burns.2010.08.009" target="_blank" title="It opens in new window">CrossRef
  14. Chen JL, Sosnov J, Lessard D et al. Use of do-not-resuscitate orders in patients with kidney disease hospitalized with acute myocardial infarction. Am J Kidney Dis. 2007; 49: 83-0. doi.org/10.1053/j.ajkd.2006.10.003" target="_blank" title="It opens in new window">CrossRef
  15. Anderson JE, Sikorski I, Finucane TE. Advance care planning by or on behalf of peritoneal dialysis patients in long-term care. Am J Kidney Dis. 2006; 48: 122-27. doi.org/10.1053/j.ajkd.2006.03.041" target="_blank" title="It opens in new window">CrossRef
  16. Messinger-Rapport BJ, Kamel H.K. Predictors of do not resuscitate orders in the nursing home. J Am Med Dir Assoc. 2005; 6: 18-1. doi.org/10.1016/j.jamda.2004.12.006" target="_blank" title="It opens in new window">CrossRef
  17. Mitchell SL, Kiely DK, Hamel MB. Dying with advanced dementia in the nursing home. Arch Intern Med. 2004; 164: 321-26. doi.org/10.1001/archinte.164.3.321" target="_blank" title="It opens in new window">CrossRef
  18. Marrie TJ, Fine MJ, Kapoor WN et al. Community-acquired pneumonia and do not resuscitate orders. J Am Geriatr Soc. 2002; 50: 290-99. doi.org/10.1046/j.1532-5415.2002.50061.x" target="_blank" title="It opens in new window">CrossRef
  19. Vaughn G, Kiyasu E, McCormick WC. Advance directive preferences among subpopulations of Asian nursing home residents in the Pacific Northwest. J Am Geriatr Soc. 2000; 48: 554-57.
  20. Ghusn HF, Teasdale TA, Boyer K. Characteristics of patients receiving or foregoing resuscitation at the time of cardiopulmonary arrest. J Am Geriatr Soc. 1997; 45: 1118-122.
  21. Bedell SE, Pelle D, Maher PL et al. Do-not-resuscitate orders for critically ill patients in the hospital. How are they used and what is their impact? Jama. 1986; 256: 233-37. doi.org/10.1001/jama.1986.03380020095030" target="_blank" title="It opens in new window">CrossRef
  22. Nathens AB, Rivara FP, Wang J et al. Variation in the rates of do not resuscitate orders after major trauma and the impact of intensive care unit environment. J Trauma. 2008; 64: 81-8. doi.org/10.1097/TA.0b013e31815dd4d7" target="_blank" title="It opens in new window">CrossRef
  23. Moss AH, Hozayen O, King K et al. Attitudes of patients toward cardiopulmonary resuscitation in the dialysis unit. Am J Kidney Dis. 2001; 38: 847-52. doi.org/10.1053/ajkd.2001.27705" target="_blank" title="It opens in new window">CrossRef
  24. Jayes RL, Zimmerman JE, Wagner DP et al. Do-not-resuscitate orders in intensive care units. Current practices and recent changes. Jama. 1993; 270: 2213-217. doi.org/10.1001/jama.1993.03510180083039" target="_blank" title="It opens in new window">CrossRef
  25. Valderas JM, Starfield B, Sibbald B et al. Defining comorbidity: implications for understanding health and health services. Ann Fam Med. 2009; 7: 357-63. doi.org/10.1370/afm.983" target="_blank" title="It opens in new window">CrossRef
  26. Hamel MB, Lynn J, Teno JM et al. Age-related differences in care preferences, treatment decisions, and clinical outcomes of seriously ill hospitalized adults: lessons from SUPPORT. J Am Geriatr Soc. 2000; 48: 176-82.
  27. Tanvetyanon T, Leighton JC. Life-sustaining treatments in patients who died of chronic congestive heart failure compared with metastatic cancer. Crit Care Med. 2003; 31: 60-4. doi.org/10.1097/00003246-200301000-00009" target="_blank" title="It opens in new window">CrossRef
  28. Haydar ZR, Lowe AJ, Kahveci KL et al. Differences in end-of-life preferences between congestive heart failure and dementia in a medical house calls program. J Am Geriatr Soc. 2004; 52: 736-40. doi.org/10.1111/j.1532-5415.2004.52210.x" target="_blank" title="It opens in new window">CrossRef
  29. Alexandrov AV, Bladin CF, Meslin EM et al. Do-not-resuscitate orders in acute stroke. Neurology. 1995; 45: 634-34. doi.org/10.1212/WNL.45.4.634" target="_blank" title="It opens in new window">CrossRef
  
• 作者单位：L. De Decker (1)
  C. Annweiler (2) (3)
  C. Launay (2)
  B. Fantino (2)
  Olivier Beauchet (2) (4)
  
  1. Department of Geriatrics, EA 1156-12, Nantes University Hospital, Nantes, France
  2. Department of Neuroscience, Division of Geriatric Medicine, UPRES EA 4638, UNAM, Angers University Hospital, Angers, France
  3. Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada
  4. Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, 49933, Angers cedex 9, France
  
• ISSN：1760-4788

文摘

Background The “Do Not Resuscitate-orders (DNR) are defined as advance medical directives to withhold cardiopulmonary resuscitation during cardiac arrest. Age-related multimorbidity may influence the DNR decision-making process. Our objective was to perform a systematic review and meta-analysis of published data examining the relationship between DNR orders and multimorbidity in older patients. Methods A systematic Medline and Cochrane literature search limited to human studies published in English and French was conducted on August 2012, with no date limits, using the following Medical Subject Heading terms: “resuscitation orders-OR “do-not-resuscitate-combined with “aged, 80 and over-combined with “comorbidities-OR “chronic diseases- Results Of the 65 selected studies, 22 met the selection criteria for inclusion in the qualitative analysis. DNR orders were positively associated with multimorbidity in 21 studies (95%). The meta-analysis included 7 studies with a total of 27,707 participants and 5065 DNR orders. It confirmed that multimorbidity were associated with DNR orders (summary OR = 1.25 [95% CI: 1.19-.33]). The relationship between DNR orders and multimorbidity differed according to the nature of morbidities; the summary OR for DNR orders was 1.15 (95% CI: 1.07-.23) for cognitive impairment, OR=2.58 (95% CI: 2.08-.20) for cancer, OR=1.07 (95% CI: 0.92-.24) for heart diseases (i.e., coronary heart disease or congestive heart failure), and OR=1.97 (95% CI: 1.61-.40) for stroke. Conclusions This systematic review and metaanalysis showed that DNR orders are positively associated with multimorbidity, and especially with three morbidities, which are cognitive impairment, cancer and stroke.