Role of Lipids in Retinal Vascular and Macular Disorders

详细信息    查看全文

• 作者：Gunjan Prakash ; Rachit Agrawal ; Tanie Natung
• 关键词：Age ; related macular degeneration ; Diabetic retinopathy ; Retinal vascular occlusion ; Stargardt disease ; Lipids
• 刊名：Indian Journal of Clinical Biochemistry
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：32
• 期：1
• 页码：3-8
• 全文大小：
• 刊物主题：Biochemistry, general; Microbiology; Chemistry/Food Science, general; Pathology;
• 出版者：Springer India
• ISSN：0974-0422
• 卷排序：32

文摘

Retinal diseases are significant by increasing problem in every part of the world. While excellent treatment has emerged for various retinal diseases, treatment for early disease is lacking due to an incomplete understanding of all molecular events. With aging, there is a striking accumulation of neutral lipids in Bruch’s membrane. These neutral lipids leads to the creation of a lipid wall at the same locations where drusen and basal linear deposit, pathognomonic lesions of Age-related macular degeneration, subsequently form. High lipid levels are also known to cause endothelial dysfunction, an important factor in the pathogenesis of Diabetic Retinopathy. Various studies suggest that 20 % of Retinal Vascular Occlusion is connected to hyperlipidemia. Biochemical studies have implicated mutation in gene encoding ABCA4, a lipid transporter in pathogenesis of Stargardt disease. This article reviews how systemic and local production of lipids might contribute to the pathogenesis of above retinal disorders.