Occurrence of intraocular air bubbles during intravitreal injections for retinopathy of prematurity

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• 作者：Emine Alyamac Sukgen ; Murat Gunay ; Yusuf Kocluk
• 关键词：Bevacizumab ; Ranibizumab ; Intravitreal air bubbles ; Intravitreal treatment ; Retinopathy of prematurity
• 刊名：International Ophthalmology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：37
• 期：1
• 页码：215-219
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Ophthalmology;
• 出版者：Springer Netherlands
• ISSN：1573-2630
• 卷排序：37

文摘

This study aims to present five cases with retinopathy of prematurity (ROP) who were found to have intraocular air bubbles after intravitreal injection (IVI) treatment. The medical records of 148 infants who underwent IVI for ROP were retrospectively reviewed and the ones who demonstrated post-injection intraocular air bubble formation were recruited. Of the 148 patients (31 babies received ranibizumab, 20 babies received aflibercept, 97 babies received bevacizumab), five were found to have intraocular air bubbles right after the IVI. Two infants received intravitreal ranibizumab and three received intravitreal bevacizumab injections. Although intraocular pressure increased temporarily, no intraocular sterile or infective reactions were observed in the postoperative period. The air bubble was found to resorb spontaneously within 72 h. The occurrence rate of the intravitreal air bubbles in our series was 3.37 % despite previously not been reported in the literature. Due to the intravitreal air injection risk, it is important to be more careful while preparing the intravitreal medication before treatment in premature babies.