Cargo trafficking in Alzheimer's disease: the possible role of retromer

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• 作者：Saeed Sadigh-Eteghad ; Mohammad Sadegh Askari-Nejad ; Javad Mahmoudi…
• 关键词：Cargo trafficking ; Alzheimer’s disease ; Retromer ; Wnt signaling ; APP processing ; Synaptic plasticity
• 刊名：Neurological Sciences
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：37
• 期：1
• 页码：17-22
• 全文大小：600 KB
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• 作者单位：Saeed Sadigh-Eteghad (1)
  Mohammad Sadegh Askari-Nejad (1)
  Javad Mahmoudi (1)
  Alireza Majdi (1)
  
  1. Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Neuroradiology
  Neurosurgery
  Psychiatry
  
• 出版者：Springer Milan
• ISSN：1590-3478

文摘

Alzheimer’s disease (AD) as one of the ongoing neurological disorders is initiated and progressed by multiple pathological pathways. Cargoes trafficking pathways, such as recycling, play a crucial role in the pathogenesis of AD. One of the major constituents of this trafficking system in neurons is retromer which acts in endosomal sorting machinery. Defective retromer disrupts recycling of cargoes from endosomes to Golgi and leads to its mis-trafficking which may subsequently leads to AD. Also, retromer-related cargo trafficking could trigger amyloidogenic pathway and beta-amyloid production. Wingless is another cargo in Wnt pathways and its trafficking is mediated by retromer. Retromer malfunction leads to lack of Wnt and subsequent AD-related pathogenesis. Also, retromer plays role in synaptic receptor trafficking in physiologic and pathologic conditions. This review is brief survey on the recent published literatures about pathogenesis of retromer-related trafficking in amyloid precursor protein pathways, Wnt signaling, synaptic function, and also revised the structural role of retromer in AD progression.