Comparative analysis of rabbit hemorrhagic disease virus strains originating from outbreaks in the Russian Federation

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• 作者：Galina Burmakina ; Nina Malogolovkina ; Andrey Lunitsin ; Ilya Titov…
• 刊名：Archives of Virology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：161
• 期：7
• 页码：1973-1979
• 全文大小：1,548 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Virology
  Medical Microbiology
  Infectious Diseases
  
• 出版者：Springer Wien
• ISSN：1432-8798
• 卷排序：161

文摘

Since the first introduction of rabbit hemorrhagic disease (RHD) in 1986, disease outbreaks have been continuously reported in different regions of Russia. Despite extensive vaccination, sporadic RHD cases are still reported. Here, we examine eleven RHDV strains originating from disease outbreaks occurring between 2003 and 2012 and one widely used vaccine strain. Notable phenotypic and genetic heterogeneity among RHDV strains was observed. The RHDV strains Tambov-2010, Perm-2010, Manihino-09 showed different hemagglutinating activity (HA) at 4 °C and room temperature. While all RHDV field strains were identified as hemagglutinating virulent viruses of the RHDVa variant, the vaccine strain was assigned as a “classical” RHDV. These data indicate that since 2003, RHDVa has become the predominant variant circulating in Russia.KeywordsRabbit hemorrhagic disease virusHemagglutinating virusesPhylogenetic analysisVP60RHDVa