Rhabdomyolyse und Erh枚hung der Kreatinkinase

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• 作者：Dr. P. Lehmann (1)
  W. Hartung (1)
  M. Fleck (1) (2)
  
• 关键词：Kreatinkinase ; Myopathie ; Organsch盲digung ; Energiestoffwechsel ; Muskelsch盲digung ; Creatine kinase ; Myopathy ; Organ damage ; Energy metabolism ; Rhabdomyolysis
• 刊名：Zeitschrift f篓鹿r Rheumatologie
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：72
• 期：3
• 页码：236-241
• 全文大小：467KB
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  14. Fachinformation Mannitol, Stand M盲rz 2011
  
• 作者单位：Dr. P. Lehmann (1)
  W. Hartung (1)
  M. Fleck (1) (2)
  
  1. Klinik f眉r Rheumatologie/Klinische Immunologie, Asklepios Klinikum Bad Abbach, Kaiser-Karl V.-Allee 3, 93077, Bad Abbach, Deutschland
  2. Klinik und Poliklinik f眉r Innere Medizin I, Universit盲tsklinikum Regensburg, Regensburg, Deutschland
  

文摘

Creatine kinase (CK) plays an important role in cellular energy metabolism in various tissues and skeletal muscle is recognized as being the largest reservoir of this enzyme. Elevated CK levels can be induced by various harmless or severe conditions implying multiple differential diagnoses for the physician. Trauma, inflammation, drug-induced toxicity, genetic disorders as well as metabolic, endocrine or rheumatic diseases might lead to cell degeneration and leakage of CK and other cellular components. Massive destruction of muscular tissue leads to rhabdomyolysis, defined as CK elevation combined with organ damage, which requires immediate diagnostic and therapeutic intervention.