Small-Scale Modeling of Pharmaceutical Powder Compression from Tap Density Testers, to Roller Compactors, and to the Tablet Press Using Big Data

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• 作者：Zhenqi Shi ; Jon L Hilden
• 关键词：Roller compaction ; Unified powder compaction model ; Powder ; Ribbon ; Tablet ; Database
• 刊名：Journal of Pharmaceutical Innovation
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：12
• 期：1
• 页码：41-48
• 全文大小：
• 刊物主题：Pharmacology/Toxicology; Industrial and Production Engineering; Biotechnology; Biochemical Engineering;
• 出版者：Springer US
• ISSN：1939-8042
• 卷排序：12

文摘

IntroductionRoller compaction is commonly used in the pharmaceutical industry to improve powder flow and compositional uniformity. The process produces ribbons which are milled into granules. The ribbon solid fraction (SF) can affect both the granule size and the tensile strength of downstream tablets. Roll force, which is directly related to the applied stress on the powder in the nip region, is typically the most dominant process parameter controlling the ribbon solid fraction. This work is an extension of a previous study, leveraging mathematical modeling as part of a Quality by Design development strategy (Powder Technology, 2011, 213: 1–13).