Anti-nociceptive effects of Carpolobia lutea G. Don (Polygalaceae) leaf fractions in animal models
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- 作者：Lucky Lebgosi Nwidu (1) (5)
Paul Alozie Nwafor (2)
Viviane Candida da Silva (3)
Clenilson Martins Rodrigues (3)
Lourdes Campaner dos Santos (3)
Wagner Vilegas (3)
Ricardo Luiz Nunes-de-Souza (4) - 关键词：Carpolobia lutea ; Polygalaceae ; Antinociceptive ; HPLC isolation of cinnamalglucosides
- 刊名：Inflammopharmacology
- 出版年：2011
- 出版时间：August 2011
- 年：2011
- 卷：19
- 期：4
- 页码：215-225
- 全文大小：665KB
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Paul Alozie Nwafor (2)
Viviane Candida da Silva (3)
Clenilson Martins Rodrigues (3)
Lourdes Campaner dos Santos (3)
Wagner Vilegas (3)
Ricardo Luiz Nunes-de-Souza (4)
1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria
5. P.O. Box 10935, Port Harcourt, Rivers State, Nigeria
2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, Nigeria
3. Departamento de Química Organica, Instituto de Química, UNESP, Univ. Estadual Paulista, CP 355, Araraquara, SP, CEP 14801-970, Brazil
4. Lab. Farmacologia, Faculdade de Ciencias, Farmaceuticas, UNESP, Univ. Estadual Paulista, UNESP Rod. Araraquara-jau, km 01, Araraquara, SP, 14801-902, Brazil - ISSN：1568-5608
文摘
Leaves from Carpolobia lutea (Polygalaceae) were screened to establish the antiulcer ethnomedicinal claim and to quantitatively isolate, elucidate the active compounds by semi-preparative HPLC. The anti-nociceptive effects of Carpolobia lutea (CL) G. Don (Polygalaceae) organic leaf extracts were tested in experimental models in mice. The anti-nociceptive mechanism was determined using tail-flick test, acetic acid-induced abdominal constrictions, formalin-induced hind paw licking and the hot plate test. The fractions (ethanol, ethyl acetate, chloroform, n-hexane) and crude ethyl acetate extract of CL (770?mg/kg, i.p.) produced significant inhibitions of both phases of the formalin-induced pain in mice, a reduction in acetic acid-induced writhing as well as and an elevation of the pain threshold in the hot plate test in mice. The inhibitions were greater to those produced by indomethacin (5?mg/kg, i.p.). Ethyl acetate fraction revealed cinnamic and coumaric acids derivatives, which are described for the first time in literature. These cinnamalglucosides polyphenols characterised from CL may in part account for the pharmacological activities. These findings confirm its ethnomedical use in anti-inflammatory pain and in pains from gastric ulcer-associated symptoms.