Effect of reinforcement volume fraction and orientation on a hybrid tissue engineered aortic heart valve with a tubular leaflet design

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• 作者：Scott E Stapleton ; Ricardo Moreira…
• 关键词：Cardiovascular tissue engineering ; Heart valve ; Anisotropic elasticity ; Large deformations ; Textile reinforced composite ; Finite elements
• 刊名：Advanced Modeling and Simulation in Engineering Sciences
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：2
• 期：1
• 全文大小：1846KB
• 参考文献：1.Iung B, Vahanian A (2011) Epidemiology of valvular heart disease in the adult. Nat Rev Cardiol 8:162-72. doi:10.-038/?nrcardio.-010.-02 CrossRef
  2.Padala M, Keeling WB, Guyton RA, Thourani VH (2011) Innovations in therapies for heart valve disease. Circ J 75:1028-041CrossRef
  3.Pibarot P, Dumesnil JG (2009) Prosthetic heart valves selection of the optimal prosthesis and long-term management. Circulation 119:1034-048. doi:10.-161/?CIRCULATIONAHA.-08.-78886 CrossRef
  4.Llames S, García E, Otero Hernández J, Meana á (2012) Tissue bioengineering and artificial organs. In: López-Larrea C, López-Vázquez A, Suárez-álvarez B (eds) Stem cell transplantation. Springer, US, pp 314-36CrossRef
  5.Butcher JT, Mahler GJ, Hockaday LA (2011) Aortic valve disease and treatment: the need for naturally engineered solutions. Adv Drug Deliv Rev 63:242-68. doi:10.-016/?j.?addr.-011.-1.-08 CrossRef
  6.Weber M, Heta E, Moreira R, Gesche VN, Schermer T, Frese J et al (2014) Tissue-engineered fibrin-based heart valve with a tubular leaflet design. Tissue Eng Part C Methods 20(4):265-75CrossRef
  7.Moreira R, Velz T, Alves N, Gesche VN, Malischewski A, Schmitz-Rode T et al (2014) Tissue-engineered heart valve with a tubular leaflet design for minimally invasive transcatheter implantation. Tissue Eng Part C Methods. doi:10.-089/?ten.?TEC.-014.-214
  8.De Hart J, Cacciola G, Schreurs PJ, Peters GW (1998) A three-dimensional analysis of a fibre-reinforced aortic valve prosthesis. J Biomech 31:629-38MATH CrossRef
  9.Cacciola G, Peters GW, Schreurs PJ (2000) A three-dimensional mechanical analysis of a stentless fibre-reinforced aortic valve prosthesis. J Biomech 33:521-30CrossRef
  10.Xiong FL, Goetz WA, Chong CK, Chua YL, Pfeifer S, Wintermantel E et al (2010) Finite element investigation of stentless pericardial aortic valves: relevance of leaflet geometry. Ann Biomed Eng 38(5):1908-918CrossRef
  11.Marom G, Haj-Ali R, Rosenfeld M, Sch?fers HJ, Raanani E (2013) Aortic root numeric model: correlation between intraoperative effective height and diastolic coaptation. J Thorac Cardiovasc Surg 145(1):303-04CrossRef
  12.Marom G, Peleg M, Halevi R, Rosenfeld M, Raanani E, Hamdan A et al (2013) Fluid-structure interaction model of aortic valve with porcine-specific collagen fiber alignment in the cusps. J Biomech Eng 135:101001-01006. doi:10.-115/-.-024824 CrossRef
  13.Cox JL, Ad N, Myers K, Gharib M, Quijano RC (2005) Tubular heart valves: a new tissue prosthesis design—preclinical evaluation of the 3F aortic bioprosthesis. J Thoracic Cardiovasc Surg 130(2):520-27CrossRef
  14.Holzapfel GA, Gasser TC (2001) A viscoelastic model for fiber-reinforced composites at finite strains: continuum basis, computational aspects and applications. Comput Methods Appl Mech Eng 190:4379-403. doi:10.-016/?S0045-7825(00)00323-6 CrossRef
  15.Ehret AE, Itskov M (2007) A polyconvex hyperelastic model for fiber-reinforced materials in application to soft tissues. J Mater Sci 42:8853-863. doi:10.-007/?s10853-007-1812-6 CrossRef
  16.Holzapfel GA (2004) Computational biomechanics of soft biological tissue. In: Encyclopedia of Computational Mechanics. Wiley. http://?onlinelibrary.?wiley.?com/?doi/-0.-002/-470091355.?ecm041/?abstract
  17.Reese S, Raible T, Wriggers P (2001) Finite element modelling of orthotropic material behaviour in pneumatic membranes. Int J Solids Struct 38:9525-544. doi:10.-016/?S0020-7683(01)00137-8 MATH CrossRef
  18.Reese S (2003) Meso-macro modelling of fibre-reinforced rubber-like composites exhibiting large elastoplastic deformation. Int J Solids Struct 40:951-80. doi:10.-016/?S0020-7683(02)00602-9 CrossRef
  19.Stier B, Simon J-W, Reese S (2014) Finite element analysis of layered fiber composite structures accounting for the material’s microstructure and delamination. Appl Compos Mater. doi:10.-007/?s10443-013-9378-8
  20.Simon J-W, H?wer D, Stier B, Reese S (2015) Meso-mechanically motivated modeling of layered fiber reinforced composites accounting for delamination. Compos Struct 122:477-87. doi:10.-016/?j.?compstruct.-014.-2.-06 CrossRef
  21.Lechat C, Bunsell AR, Davies P (2010) Tensile and creep behaviour of polyethylene terephthalate and polyethylene naphthalate fibres. J Mater Sci 46:528-33. doi:10.-007/?s10853-010-4999-x CrossRef
  22.Flanagan TC, Cornelissen C, Koch S, Tschoeke B, Sachweh JS, Schmitz-Rode T et al (2007) The in vitro development of autologous fibrin-based tissue-engineered heart valves through optimised dynamic conditioning. Biomaterials 28(23):3388-397CrossRef
  23.Bardy J, Legrand X, Crosky A (2012) Configuration of a genetic algorithm used to optimise fibre steering in composite laminates. Compos Struct 94:2048-056. doi:10.-016/?j.?compstruct.-011.-2.-19 CrossRef
  24.Legrand X, Kelly D, Crosky A, Crépin D (2006) Optimisation of fibre steering in composite laminates using a genetic algorithm. Compos Str
• 作者单位：Scott E Stapleton (1)
  Ricardo Moreira (2)
  Stefan Jockenhoevel (2)
  Petra Mela (2)
  Stefanie Reese (3)
  
  1. Department of Mechanical Engineering, University of Massachusetts Lowell, Lowell, MA, 01854, USA
  2. Department of Tissue Engineering and Textile Implants, Institute of Applied Medical Engineering, RWTH Aachen University, Aachen, 52074, Germany
  3. Institute of Applied Mechanics, RWTH Aachen University, Aachen, 52074, Germany
  
• 刊物类别：Theoretical and Applied Mechanics; Computational Science and Engineering; Classical Continuum Physic
• 刊物主题：Theoretical and Applied Mechanics; Computational Science and Engineering; Classical Continuum Physics;
• 出版者：Springer International Publishing
• ISSN：2213-7467

文摘

Transcatheter aortic valve implantation of fibrin-based tissue engineered heart valves with a tubular leaflet construct have been developed as an alternative to invasive traditional surgical heart valve implantation. In general, they are well suited for the pulmonary position, but display insufficient mechanical properties for the aortic position. To enable the application of tissue-engineered valves in the systemic circulation, the tissue is reinforced with a textile scaffold. The current study seeks to compare the effect of varying the fiber volume fraction and orientation of bidirectional textile reinforcement on the closed-valve configuration. An anisotropic large deformation material model based on structural tensors was chosen and the materials were characterized. A finite element model was constructed of the heart valve, and the pinching and suturing of the corners along with application of pressure was simulated. Virtual experiments were conducted with fiber volume fractions of 0.1, 0.01, 0.001, and 0.0001 for ±45° fiber orientations. Furthermore, volume fraction was held at 0.01 and fiber orientations of 0°, ±15°, ±30°, ±45°, ±60°, ±75° and 90° from the tube’s axial direction were simulated and compared. It was shown that increasing the fiber volume fraction decreased the maximum principle strain in the valve, but lead to less closure. Additionally, the effect of fiber orientation affected the strains differently at different locations, depending on the local deformed geometry. This indicates that a non-uniform fiber distribution using tailored fiber placement could be used to optimize reinforcement design. Keywords Cardiovascular tissue engineering Heart valve Anisotropic elasticity Large deformations Textile reinforced composite Finite elements