High-Resolution Peripheral Quantitative Computed Tomography for the Assessment of Bone Strength and Structure: A Review by the Canadian Bone Strength Working Group
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- 作者：Angela M. Cheung (1)
Jonathan D. Adachi (2)
David A. Hanley (3)
David L. Kendler (4)
K. Shawn Davison (5)
Robert Josse (6)
Jacques P. Brown (7)
Louis-Georges Ste-Marie (8)
Richard Kremer (9)
Marta C. Erlandson (10) (6)
Larry Dian (4)
Andrew J. Burghardt (11)
Steven K. Boyd (12) - 关键词：High ; resolution peripheral quantitative computed tomography ; Bone strength ; Assessment ; Bone microarchitecture ; Volumetric BMD ; Fracture ; Age ; Therapy ; Finite element analysis
- 刊名：Current Osteoporosis Reports
- 出版年：2013
- 出版时间：June 2013
- 年：2013
- 卷：11
- 期：2
- 页码：136-146
- 全文大小：418KB
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Jonathan D. Adachi (2)
David A. Hanley (3)
David L. Kendler (4)
K. Shawn Davison (5)
Robert Josse (6)
Jacques P. Brown (7)
Louis-Georges Ste-Marie (8)
Richard Kremer (9)
Marta C. Erlandson (10) (6)
Larry Dian (4)
Andrew J. Burghardt (11)
Steven K. Boyd (12)
1. Centre of Excellence in Skeletal Health Assessment, Department of Medicine and Joint Department of Medical Imaging, University Health Network, University of Toronto, Toronto, ON, Canada
2. Department of Medicine, Michael G. DeGroote School of Medicine, St. Joseph鈥檚 Healthcare 鈥?McMaster University, Hamilton, ON, Canada
3. Department of Medicine, University of Calgary, Calgary, AB, Canada
4. Department of Medicine, University of British Columbia, Vancouver, BC, Canada
5. University of Victoria, Victoria, BC, Canada
6. Department of Medicine, University of Toronto, Toronto, ON, Canada
7. Department of Medicine, Laval University, Quebec City, PQ, Canada
8. Department of Medicine, Universit茅 de Montr茅al, Montreal, PQ, Canada
9. Department of Medicine, McGill University, Montreal, PQ, Canada
10. Osteoporosis and Women鈥檚 Health Programs, University Health Network, Toronto, Canada
11. Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
12. McCaig Institute for Bone and Joint Health, Department of Radiology, University of Calgary, 3280 Hospital Drive, NW, Calgary, Alberta, T2N 4Z6, Canada
文摘
Bone structure is an integral determinant of bone strength. The availability of high resolution peripheral quantitative computed tomography (HR-pQCT) has made it possible to measure three-dimensional bone microarchitecture and volumetric bone mineral density in vivo, with accuracy previously unachievable and with relatively low-dose radiation. Recent studies using this novel imaging tool have increased our understanding of age-related changes and sex differences in bone microarchitecture, as well as the effect of different pharmacological therapies. One advantage of this novel tool is the use of finite element analysis modelling to non-invasively estimate bone strength and predict fractures using reconstructed three-dimensional images. In this paper, we describe the strengths and limitations of HR-pQCT and review the clinical studies using this tool.