Prevalence of influenza A viruses in livestock and free-living waterfowl in Uganda

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• 作者：Halid Kirunda (1)
  Bernard Erima (2)
  Agnes Tumushabe (2)
  Jocelyn Kiconco (2)
  Titus Tugume (2)
  Sophia Mulei (2)
  Derrick Mimbe (2)
  Edison Mworozi (3)
  Josephine Bwogi (4)
  Lukwago Luswa (5)
  Hannah Kibuuka (2)
  Monica Millard (2)
  Achilles Byaruhanga (6)
  Mariette F Ducatez (7)
  Scott Krauss (8)
  Richard J Webby (8)
  Robert G Webster (8)
  Kofi Wurapa (9)
  Denis K Byarugaba (10) (2)
  Fred Wabwire-Mangen (11)
  
• 关键词：Influenza A viruses ; Poultry ; Pigs ; RNA ; Sera ; Free ; living ; Waterfowl
• 刊名：BMC Veterinary Research
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：10
• 期：1
• 全文大小：277 KB
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• 作者单位：Halid Kirunda (1)
  Bernard Erima (2)
  Agnes Tumushabe (2)
  Jocelyn Kiconco (2)
  Titus Tugume (2)
  Sophia Mulei (2)
  Derrick Mimbe (2)
  Edison Mworozi (3)
  Josephine Bwogi (4)
  Lukwago Luswa (5)
  Hannah Kibuuka (2)
  Monica Millard (2)
  Achilles Byaruhanga (6)
  Mariette F Ducatez (7)
  Scott Krauss (8)
  Richard J Webby (8)
  Robert G Webster (8)
  Kofi Wurapa (9)
  Denis K Byarugaba (10) (2)
  Fred Wabwire-Mangen (11)
  
  1. National Livestock Resources Research Institute, P.O. Box 96, Tororo, Uganda
  2. Makerere University Walter Reed Project, P.O. Box 16524, Kampala, Uganda
  3. Department of Paediatrics and Child Health/Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7072, Kampala, Uganda
  4. Uganda Virus Research Institute, P.O. Box 49, Entebbe, Uganda
  5. Epidemiology and Surveillance Division, Ministry of Health, P.O. Box 7272, Kampala, Uganda
  6. NatureUganda, The East Africa Natural History Society, P.O. Box 27034, Kampala, Uganda
  7. INRA UMR1225 IHAP Interactions h么tes-agents pathog猫nes, ENVT, Toulouse, France
  8. Department of Infectious Diseases, St. Jude Children鈥檚 Research Hospital, Memphis, USA
  9. U.S. Army Medical Research Unit-Kenya, U.S. Embassy, P.O. Box 606, Nairobi, Kenya
  10. College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, P.O. Box 7062, Kampala, Uganda
  11. School of Public Health, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda
  
• ISSN：1746-6148

文摘

Background Avian influenza viruses may cause severe disease in a variety of domestic animal species worldwide, with high mortality in chickens and turkeys. To reduce the information gap about prevalence of these viruses in animals in Uganda, this study was undertaken. Results Influenza A virus prevalence by RT-PCR was 1.1% (45/4,052) while seroprevalence by ELISA was 0.8% (24/2,970). Virus prevalence was highest in domestic ducks (2.7%, 17/629) and turkeys (2.6%, 2/76), followed by free-living waterfowl (1.3%, 12/929) and swine (1.4%, 7/511). A lower proportion of chicken samples (0.4%, 7/1,865) tested positive. No influenza A virus was isolated. A seasonal prevalence of these viruses in waterfowl was 0.7% (4/561) for the dry and 2.2% (8/368) for the wet season. In poultry, prevalence was 0.2% (2/863) for the dry and 1.4% (24/1,713) for the wet season, while that of swine was 0.0% (0/159) and 2.0% (7/352) in the two seasons, respectively. Of the 45 RT-PCR positive samples, 13 (28.9%) of them were H5 but none was H7. The 19 swine sera positive for influenza antibodies by ELISA were positive for H1 antibodies by HAI assay, but the subtype(s) of ELISA positive poultry sera could not be determined. Antibodies in the poultry sera could have been those against subtypes not included in the HAI test panel. Conclusions The study has demonstrated occurrence of influenza A viruses in animals in Uganda. The results suggest that increase in volumes of migratory waterfowl in the country could be associated with increased prevalence of these viruses in free-living waterfowl and poultry.