Heritable changes in regional cortical thickness with age

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• 作者：Francois Chouinard-Decorte (1)
  D. Reese McKay (2) (3)
  Andrew Reid (1)
  Budhachandra Khundrakpam (1)
  Lu Zhao (1)
  Sherif Karama (1) (4)
  Pierre Rioux (1)
  Emma Sprooten (2) (3)
  Emma Knowles (2) (3)
  Jack W. Kent Jr. (5)
  Joanne E. Curran (5)
  Harald H. H. G?ring (5)
  Thomas D. Dyer (5)
  Rene L. Olvera (1) (2) (3) (4) (5) (6) (7) (8) (9)
  Peter Kochunov (6)
  Ravi Duggirala (5)
  Peter T. Fox (7)
  Laura Almasy (5)
  John Blangero (5)
  Pierre Bellec (8)
  Alan C. Evans (1)
  David C. Glahn (2) (3)
  
• 关键词：Cortical Thickness ; Heritability ; Genotype by Age Interaction ; Clustering
• 刊名：Brain Imaging and Behavior
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：8
• 期：2
• 页码：208-216
• 全文大小：
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• 作者单位：Francois Chouinard-Decorte (1)
  D. Reese McKay (2) (3)
  Andrew Reid (1)
  Budhachandra Khundrakpam (1)
  Lu Zhao (1)
  Sherif Karama (1) (4)
  Pierre Rioux (1)
  Emma Sprooten (2) (3)
  Emma Knowles (2) (3)
  Jack W. Kent Jr. (5)
  Joanne E. Curran (5)
  Harald H. H. G?ring (5)
  Thomas D. Dyer (5)
  Rene L. Olvera (1) (2) (3) (4) (5) (6) (7) (8) (9)
  Peter Kochunov (6)
  Ravi Duggirala (5)
  Peter T. Fox (7)
  Laura Almasy (5)
  John Blangero (5)
  Pierre Bellec (8)
  Alan C. Evans (1)
  David C. Glahn (2) (3)
  
  1. McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada
  2. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06571, USA
  3. Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, 06106, USA
  4. Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, H4H 1R2, Canada
  5. Department of Genetics, Texas Biomedical Research Institute, PO Box 760549, San Antonio, TX, 78245, USA
  6. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 2120, USA
  7. Research Imaging Institute, University of Texas Health Science Center San Antonio, 8403 Floyd Curl Dr, San Antonio, TX, 78229, USA
  8. Geriatric Institute Research Center, Université de Montréal, Montréal, QC, H3W 1W5, Canada
  9. Department of Psychiatry, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, H3W 1W5, USA
  
• ISSN：1931-7565

文摘

It is now well established that regional indices of brain structure such as cortical thickness, surface area or grey matter volume exhibit spatially variable patterns of heritability. However, a recent study found these patterns to change with age during development, a result supported by gene expression studies. Changes in heritability have not been investigated in adulthood so far and could have important implications in the study of heritability and genetic correlations in the brain as well as in the discovery of specific genes explaining them. Herein, we tested for genotype by age (G ×A) interactions, an extension of genotype by environment interactions, through adulthood and healthy aging in 902 subjects from the Genetics of Brain Structure (GOBS) study. A “jackknife-based method for the analysis of stable cortical thickness clusters (JASC) and scale selection is also introduced. Although additive genetic variance remained constant throughout adulthood, we found evidence for incomplete pleiotropy across age in the cortical thickness of paralimbic and parieto-temporal areas. This suggests that different genetic factors account for cortical thickness heritability at different ages in these regions.