Mechanisms and Mediators That Drive Arthritis Pain

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• 作者：Eugene Krustev ; Danielle Rioux ; Jason J. McDougall
• 关键词：Arthritis ; Pain ; Inflammation ; Neuropathic pain ; Cytokines ; Neurogenic inflammation ; Proteinases ; Cannabinoids ; Voltage ; gated ion channels ; Nerve growth factor
• 刊名：Current Osteoporosis Reports
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：13
• 期：4
• 页码：216-224
• 全文大小：223 KB
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• 作者单位：Eugene Krustev (1)
  Danielle Rioux (1)
  Jason J. McDougall (1) (2)
  
  1. Department of Pharmacology, Dalhousie University, 5850 College Street, Halifax, NS, B3H 4R2, Canada
  2. Department of Anaesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College Street, Halifax, NS, B3H 4R2, Canada
  
• 刊物主题：Orthopedics; Epidemiology;
• 出版者：Springer US
• ISSN：1544-2241

文摘

There are over 100 different types of arthritis and each can differ greatly in their aetiology and pathophysiology; however, one characteristic that is common to all arthritic conditions is joint pain. Musculoskeletal pain is the leading cause of disability in the world, and the number one reason arthritis patients visit their primary care physician. Despite the prevalence and burden of arthritis pain, current analgesics lack sufficient efficacy and are plagued by multiple adverse side effects. In this review, we outline the current landscape of research concerning joint pain, drawing from both preclinical and clinical studies. Specifically, this review is a discussion of the different neurophysiological processes that occur during joint disease and how inflammatory and neuropathic aspects contribute to the development of arthritis pain.