A study of the synthesis of triazoles using microwave irradiation

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• 作者：Kenneth A. Savin ; Michael Robertson ; Doug Gernert ; Steven Green ; Erik J. Hembre and Jessie Bishop
• 关键词：[3+2] cycloaddition ; flow ; through reaction ; microwave irradiation ; montmorillonite (K ; 10) clay ; triazole
• 刊名：Molecular Diversity
• 出版年：2003
• 出版时间：June 2003
• 年：2003
• 卷：7
• 期：2-4
• 页码：171-174
• 全文大小：61 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Polymer Sciences
  Organic Chemistry
  Pharmacy
  
• 出版者：Springer Netherlands
• ISSN：1573-501X

文摘

Herein we describe the conversion of a known [3+2] cycloaddition reaction between an azide and an acetylene from a thermally promoted reaction to a microwave assisted process. Modification of conditions including concentration, temperature, solvent type and time were investigated. This methodology study led us to use high concentration and high temperatures to achieve the desired fast reaction times and high yields.