Cerebellar and Motor Cortical Transcranial Stimulation Decrease Levodopa-Induced Dyskinesias in Parkinson’s Disease

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• 作者：Roberta Ferrucci ; Francesca Cortese ; Marta Bianchi ; Dario Pittera…
• 关键词：Cerebellum ; tDCS ; Cerebellar tDCS ; Parkinson ; Levodopa ; induced dyskinesias
• 刊名：The Cerebellum
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：15
• 期：1
• 页码：43-47
• 全文大小：350 KB
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• 作者单位：Roberta Ferrucci (1) (2)
  Francesca Cortese (1)
  Marta Bianchi (3)
  Dario Pittera (1)
  Rosanna Turrone (3)
  Tommaso Bocci (1) (4)
  Barbara Borroni (3)
  Maurizio Vergari (1)
  Filippo Cogiamanian (1)
  Gianluca Ardolino (1)
  Alessio Di Fonzo (1)
  Alessandro Padovani (3)
  Alberto Priori (1) (2) (5)
  
  1. Fondazione IRCCS Ca’ Granda, Milan, Italy
  2. Università degli Studi di Milano, Milan, Italy
  3. Spedali Civili di Brescia, Università degli Studi di Brescia, Brescia, Italy
  4. Università degli Studi di Pisa, Pisa, Italy
  5. III Clinica Neurologica, Polo Ospedaliero San Paolo, Milan, Italy
  
• 刊物主题：Neurosciences; Neurology; Neurobiology;
• 出版者：Springer US
• ISSN：1473-4230

文摘

Transcranial direct current stimulation (tDCS) is a non-invasive technique for inducing prolonged functional changes in the human cerebral cortex. This simple and safe neurostimulation technique for modulating motor functions in Parkinson’s disease could extend treatment option for patients with movement disorders. We assessed whether tDCS applied daily over the cerebellum (cerebellar tDCS) and motor cortex (M1-tDCS) improves motor and cognitive symptoms and levodopa-induced dyskinesias in patients with Parkinson’s disease (PD). Nine patients (aged 60–85 years; four women; Hoehn & Yahr scale score 2–3) diagnosed as having idiopathic PD were recruited. To evaluate how tDCS (cerebellar tDCS or M1-tDCS) affects motor and cognitive function in PD, we delivered bilateral anodal (2 mA, 20 min, five consecutive days) and sham tDCS, in random order, in three separate experimental sessions held at least 1 month apart. In each session, as outcome variables, patients underwent the Unified Parkinson’s Disease Rating Scale (UPDRS III and IV) and cognitive testing before treatment (baseline), when treatment ended on day 5 (T1), 1 week later (T2), and then 4 weeks later (T3), at the same time each day. After patients received anodal cerebellar tDCS and M1-tDCS for five days, the UPDRS IV (dyskinesias section) improved (p < 0.001). Conversely, sham tDCS, cerebellar tDCS, and M1-tDCS left the other variables studied unchanged (p > 0.05). Despite the small sample size, our preliminary results show that anodal tDCS applied for five consecutive days over the motor cortical areas and cerebellum improves parkinsonian patients’ levodopa-induced dyskinesias. Keywords Cerebellum tDCS Cerebellar tDCS Parkinson Levodopa-induced dyskinesias