Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation

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• 作者：Roberto Buda ; Francesca Vannini ; Francesco Castagnini…
• 关键词：Ankle ; Osteochondral lesions ; Regenerative techniques ; Bone marrow ; Autologous chondrocytes implantation ; T2 mapping
• 刊名：International Orthopaedics
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：39
• 期：5
• 页码：893-900
• 全文大小：2,448 KB
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• 作者单位：Roberto Buda (1)
  Francesca Vannini (1)
  Francesco Castagnini (1)
  Marco Cavallo (1)
  Alberto Ruffilli (1)
  Laura Ramponi (1)
  Gherardo Pagliazzi (1)
  Sandro Giannini (1)
  
  1. Orthopaedics and Traumatology, I Clinic, Rizzoli Orthopaedic Institute, University of Bologna, Bologna, Italy
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Orthopedics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-5195

文摘

Purpose Osteochondral lesions of the talus (OLT) usually require surgical treatment. Regenerative techniques for hyaline cartilage restoration, like autologous chondrocytes implantation (ACI) or bone marrow derived cells transplantation (BMDCT), should be preferred. The aim of this work is comparing two clusters with OLT, treated with ACI or BMDCT. Methods Eighty patients were treated with regenerative techniques, 40 with ACI and 40 with BMDCT. The two groups were homogenous regarding age, lesion size and depth, previous surgeries, etiology of the lesion, subchondral bone graft, final follow-up and pre-operative AOFAS score. The two procedures were performed arthroscopically. The scaffold was a hyaluronic acid membrane in all the cases, loaded with previously cultured chondrocytes (ACI) or with bone marrow concentrated cells, harvested in the same surgical session (BMDCT). All the patients were clinically and radiologically evaluated, using MRI Mocart score and T2 mapping sequence. Results Clinical results were similar in both groups at 48?months. No statistically significant influence was reported after evaluation of all the pre-operative parameters. The rate of return to sport activity showed slightly better results for BMDCT than ACI. MRI Mocart score was similar in both groups. MRI T2 mapping evaluation highlighted a higher presence of hyaline like values in the BMDCT group, and lower incidence of fibrocartilage as well. Conclusions To date, ACI and BMDCT showed to be effective regenerative techniques for the treatment of OLT. BMDCT could be preferred over ACI for the single step procedure, patients-discomfort and lower costs.