Chlamydia trachomatis infection and human papillomavirus in women with cervical neoplasia in Pernambuco-Brazil

详细信息    查看全文

• 作者：Mayara Costa Mansur Tavares (1)
  Jamilly Lopes de Macêdo (2)
  Sérgio Ferreira de Lima Júnior (1)
  Sandra de Andrade Heráclio (3)
  Melania Maria Ramos Amorim (4)
  Maria de Mascena Diniz Maia (5)
  Paulo Roberto Eleutério de Souza (5)
  
• 关键词：Human papillomavirus ; Abnormal cytology ; Chlamydia trachomatis ; Risk factors ; Brazilian population
• 刊名：Molecular Biology Reports
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：41
• 期：2
• 页码：865-874
• 全文大小：383 KB
• 作者单位：Mayara Costa Mansur Tavares (1)
  Jamilly Lopes de Macêdo (2)
  Sérgio Ferreira de Lima Júnior (1)
  Sandra de Andrade Heráclio (3)
  Melania Maria Ramos Amorim (4)
  Maria de Mascena Diniz Maia (5)
  Paulo Roberto Eleutério de Souza (5)
  
  1. Master in Biology Applied to Health, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil
  2. Master in Applied Molecular and Cellular Biology, Universidade de Pernambuco (UPE), Recife, PE, Brazil
  3. Departament of Lower Genital Tract Pathology, Women’s Healthcare Center, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brazil
  4. Maternal and Child Healthcare Departament, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brazil
  5. Biology Department, Universidade Federal Rural de Pernambuco (UFRPE), Recife, PE, Brazil
  
• ISSN：1573-4978

文摘

Chlamydia trachomatis (CT) is the most common bacterial cause of sexually transmitted disease. High-risk human papillomavirus (HR-HPV) is considered the main etiological agent for cervical neoplasia. Evidences showed that the presence of co-infection of CT and HR-HPV plays a central role in the etiology of cervical intraepithelial neoplasia (CIN) and cervical cancer. The goals of this study were: evaluate the human papillomavirus (HPV) and CT prevalence among Brazilian women with abnormal cytology and provide the effect of this association on the severity of cervical neoplasia. The population of this study was composed by 142 women with incident histological incidence of CIN grades I, II, III or cervical cancer from Recife, Northeast of Brazil. The polymerase chain reaction method on a cervical brush specimen was used to detect both agents and the automatic sequencing method was used for HPV genotyping assay. The prevalence of HPV and CT was 100 and 24.65?%, respectively. Thirteen types of HPV were detected; HPV 16, 18, 31 and 33 were the most common. The most prevalent HPV types were HPV 16 and 18. A significant association between CT positive and HPV 16 infection was found (p?<?0.0106; OR?=?5.31; 95?% IC?1.59-7.67). In the study population, there was diversity of HPV infections, with high-risk types being the most common. Also, the data collected suggest that CT infection may play an important role in the natural history of HPV infection.