Revisiting a Classic Study of the Molecular Clock

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• 作者：Lauren M. Robinson ; Joseph R. Boland ; John M. Braverman
• 关键词：Molecular clock ; Constant rate of evolution ; Protein evolution ; Dickerson’s graph
• 刊名：Journal of Molecular Evolution
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：82
• 期：2-3
• 页码：110-116
• 全文大小：536 KB
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• 作者单位：Lauren M. Robinson (1)
  Joseph R. Boland (1)
  John M. Braverman (1)
  
  1. Department of Biology, Saint Joseph’s University, 5600 City Ave., Philadelphia, PA, 19131, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Microbiology
  Plant Sciences
  
• 出版者：Springer New York
• ISSN：1432-1432

文摘

A constant rate of molecular evolution among homologous proteins and across lineages is known as the molecular clock. This concept has been useful for estimating divergence times. Here, we revisit a study by Richard Dickerson (J Mol Evol 1:26–45, 1971), wherein he provided striking visual evidence for a constant rate of amino acid changes among various evolutionary branch points. Dickerson’s study is commonly cited as support of the molecular clock and a figure from it is often reproduced in textbooks. Since its publication, however, there have been updates made to dates of common ancestors based on the fossil record that should be considered. Additionally, collecting the accession numbers and carefully outlining Dickerson’s methods serves as a resource to students of the molecular clock hypothesis.