参考文献:1.Kaneko Y, Nimmerjahn F, Ravetch JV: Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation. Science. 2006, 313 (5787): 670-673.PubMed CrossRef 2.Scallon BJ, Tam SH, McCarthy SG, Cai AN, Raju TS: Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality. Mol Immunol. 2007, 44 (7): 1524-1534.PubMed CrossRef 3.Yu X, Baruah K, Harvey DJ, Vasiljevic S, Alonzi DS, Song B-D, Higgins MK, Bowden Ta, Scanlan CN, Crispin M: Engineering hydrophobic protein-carbohydrate interactions to fine-tune monoclonal antibodies. J Am Chem Soc. 2013, 135: 9723-9732.PubMed PubMedCentral CrossRef 4.Raymond C, Robotham A, Spearman M, Butler M, Kelly J, Durocher Y: Production of alpha2,6-sialylated IgG1 in CHO cells. mAbs. 2015, 7 (3): 571-583.PubMed CrossRef
作者单位:Céline Raymond (1) (2) Anna Robotham (3) Maureen Spearman (4) Michael Butler (4) John Kelly (3) Yves Durocher (1) (2)
1. Human Health Therapeutics Portfolio, National Research Council of Canada, Montreal, Quebec, H4P 2R2, Canada 2. Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal, Quebec, H3C 3J7, Canada 3. Human Health Therapeutics Portfolio, National Research Council of Canada, Ottawa, Ontario, K1A 0R6, Canada 4. Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada