A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data

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• 作者：Xavier Sáez-Llorens (31)
  F Raúl Velázquez (29)
  Pio Lopez (30)
  Felix Espinoza (31)
  Alexandre C Linhares (29)
  Hector Abate (30)
  Ernesto Nu?ez (31)
  Guillermo Venegas (31)
  Rodrigo Vergara (29)
  Ana L Jimenez (30)
  Maribel Rivera (31)
  Carlos Aranza (29)
  Vesta Richardson (30) (31)
  Mercedes Macias-Parra (31)
  Guillermo Ruiz Palacios (29)
  Luis Rivera (30)
  Eduardo Ortega-Barria (29) (31)
  Yolanda Cervantes (29)
  Ricardo Rüttimann (30) (30)
  Pilar Rubio (29) (31)
  Camilo J Acosta (29) (31)
  Claire Newbern (29) (30)
  Thomas Verstraeten (30) (30)
  Thomas Breuer (30) (31)
  
• 关键词：Intussusception ; Latin America ; Vaccination ; Rotavirus ; Multi country ; Children
• 刊名：BMC Gastroenterology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：13
• 期：1
• 全文大小：252KB
• 参考文献：1. Wyllie R: Ileus, adhesions, intussusception and closed-loop obstructions. In / Nelson textbook of pediatrics. 15th edition. Edited by: Behrman RE, Kliegman RM, Arvin AM. Philadelphia: WB Saunders; 1997:1072-074.
  2. Bhisitkul DM, Todd KM, Listernick R: Adenovirus infection and childhood intussusceptions. / Am J Dis Child 1992, 146:1331-333.
  3. Mulcahy DL, Kamath KR, De Silva LM, Hodges S, Carter IW, Cloonan MJ: A two-part study of the aetiological role of rotavirus in intussusceptions. / J Med Virol 1982, 9:51-5. CrossRef
  4. Asano Y, Yoshikawa T, Suga S, Hata T, Yamazaki T, Yazaki T: Simultaneous occurrence of human herpesvirus 6 infection and intussusception in three infants. / Pediatr Infect Dis J 1991, 10:335-37. CrossRef
  5. Nakagomi T: Rotavirus infection and intussusception: a view from retrospect. / Microbiol Immunol 2000, 44:619-28.
  6. Velázquez FR, Luna G, Cedillo R, Torres J, Mu?oz O: Natural rotavirus infection is not associated to intussusception in Mexican children. / Pediatr Infect Dis J 2004,23(Suppl 10):S173-S178.
  7. Rennels MB, Parashar UD, Holman RC, Le CT, Chang HG, Glass RI: Lack of an apparent association between intussusception and wild or vaccine rotavirus infection. / Pediatr Infect Dis J 1998, 17:924-25. CrossRef
  8. Nelson EA, Tam JS, Glass RI, Parashar UD, Fok TF: Incidence of rotavirus diarrhea and intussusception in Hong Kong using standardized hospital discharge data. / Pediatr Infect Dis J 2002, 21:701-03. CrossRef
  9. Chang HG, Smith PF, Ackelsberg J, Morse DL, Glass RI: Intussusception, rotavirus diarrhea, and rotavirus vaccine use among children in New York State. / Pediatrics 2001, 108:54-0. CrossRef
  10. Chen YE, Beasley S, Grimwood K, and the New Zealand Rotavirus Study Group: Intussusception and rotavirus associated hospitalisation in New Zealand. / Arch Dis Child 2005, 90:1077-081. CrossRef
  11. Bines JE: Rotavirus vaccines and intussusception risk. / Curr Opin Gastroenterol 2005, 21:20-5.
  12. Widdowson MA, Bresee JS, Gentsch JR, Glass RI: Rotavirus disease and its prevention. / Curr Opin Gastroenterol 2004, 21:26-1.
  13. Murphy TV, Gargiullo PM, Massoudi MS, Nelson DB, Jumaan AO, Okoro CA, Zanardi LR, Setia S, Fair E, LeBaron CW, Wharton M, Livengood JR, for the Rotavirus Intussusception Investigation Team: Intussusception among infants given an oral rotavirus vaccine. / N Engl J Med 2001, 344:564-72. CrossRef
  14. World Health Organization Initiative for Vaccine Research (IVR): / State of the art of new vaccines: research & development. [http://www.who.int/vaccine_research/documents/stateoftheart/en/]
  15. Fischer TK, Bresee JS, Glass RI: Rotavirus vaccines and the prevention of hospital-acquired diarrhea in children. / Vaccine 2004,22(Suppl 1):S49-S54. CrossRef
  16. Ruiz-Palacios GM, Pérez-Schael I, Velázquez FR, Abate H, Breuer T, Clemens SC, Cheuvart B, Espinoza F, Gillard P, Innis BL, Cervantes Y, Linhares AC, López P, Macías-Parra M, Ortega-Barría E, Richardson V, Rivera-Medina DM, Rivera L, Salinas B, Pavía-Ruz N, Salmerón J, Rüttimann R, Tinoco JC, Rubio P, Nu?ez E, Guerrero ML, Yarzábal JP, Damaso S, Tornieporth N, Sáez-Llorens X: Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. / N Engl J Med 2006, 354:11-2. CrossRef
  17. Vesikari T, Matson DO, Dennehy P, Van Damme P, Santosham M, Rodriguez Z, Dallas MJ, Heyse JF, Goveia MG, Black SB, Shinefield HR, Christie CD, Ylitalo S, Itzler RF, Coia ML, Onorato MT, Adeyi BA, Marshall GS, Gothefors L, Campens D, Karvonen A, Watt JP, O'Brien KL, DiNubile MJ, Clark HF, Boslego JW, Offit PA, Heaton PM, Rotavirus Efficacy and Safety Trial (REST) Study Team: Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. / N Engl J Med 2006, 354:23-3. CrossRef
  18. De Oliveira LH, Danovaro-Holliday MC, Sanwogou JN, Ruiz-Matus C, Tambini G, Andrus J: Progress in the introduction of the rotavirus vaccine in Latin America and the Caribbean: four years of accumulated experience. / Pediatr Infect Dis J 2011,30(Suppl 1):S61-S66.
  19. Patel MM, López-Collada VR, Bulh?es MM, De Oliveira LH, Bautista Márquez A, Flannery B, Esparza-Aguilar M, Montenegro Renoiner EI, Luna-Cruz ME, Sato HK, Hernández-Hernández Ldel C, Toledo-Cortina G, Cerón-Rodríguez M, Osnaya-Romero N, Martínez-Alcazar M, Aguinaga-Villasenor RG, Plascencia-Hernández A, Fojaco-González F, Hernández-Peredo Rezk G, Gutierrez-Ramírez SF, Dorame-Castillo R, Tinajero-Pizano R, Mercado-Villegas B, Barbosa MR, Maluf EM, Ferreira LB, de Carvalho FM, dos Santos AR, Cesar ED, de Oliveira ME: Intussusception risk and health benefits of rotavirus vaccination in Mexico. / N Engl J Med 2011, 364:2283-292. CrossRef
  20. Velázquez FR, Colindres RE, Grajales C, Hernández MT, Mercadillo MG, Torres FJ, Cervantes-Apolinar M, DeAntonio-Suarez R, Ortega-Barria E, Blum M, Breuer T, Verstraeten T: Post-marketing surveillance of intussusception following mass introduction of the attenuated human rotavirus vaccine in Mexico. / Pediar Infect Dis J 2012, 31:736-44. CrossRef
  21. Desai R, Parashar UD, Lopman B, de Oliveira LH, Clark AD, Sanderson CF, Tate JE, Matus CR, Andrus JK, Patel MM: Potential intussusception risk versus health benefits from rotavirus vaccination in Latin America. / Clin Infect Dis 2012, 54:1397-405. CrossRef
  22. Bines JE, Kohl KS, Forster J, Zanardi LR, Davis RL, Hansen J, Murphy TM, Music S, Niu M, Varricchio F, Vermeer P, Wong EJ, Brighton Collaboration Intussusception Working Group: Acute intussusception in infants and children as an adverse event following immunization: case definition and guidelines of data collection, analysis, and presentation. / Vaccine 2004, 22:569-74. CrossRef
  23. Tapiainen T, B?r G, Bonhoeffer J, Heininger U: Evaluation of the Brighton Collaboration case definition of acute intussusception during active surveillance. / Vaccine 2006, 24:1483-487. CrossRef
  24. Buettcher M, Baer G, Bonhoeffer J, Schaad UB, Heininger U: Three-year surveillance of intussusception in children in Switzerland. / Pediatrics 2007, 120:473-80. CrossRef
  25. Gay N, Ramsay M, Waight P: Rotavirus vaccination and intussusception. / Lancet 1999, 354:956. CrossRef
  26. Fischer TK, Bihrmann K, Perch M, Koch A, Wohlfahrt J, K?re M, Melbye M: Intussusception in early childhood: a cohort study of 1.7 million children. / Pediatrics 2004, 114:782-85. CrossRef
  27. Justice FA, Auldist AW, Bines JE: Intussusception: Trends in clinical presentation and management. / J Gastroenterol Hepatol 2006, 21:842-46. CrossRef
  28. Huppertz HI, Soriano-Gabarró M, Grimprel E, Franco E, Mezner Z, Desselberger U, Smit Y, Wolleswinkel-van den Bosch J, De Vos B, Giaquinto C: Intussusception among young children in Europe. / Pediatr Infect Dis J 2006,25(Suppl1):S22-S29.
  29. Sáez-Llorens X, Guevara JN: Intussusception and rotavirus vaccines: what is the background risk. / Pediatr Infect Dis J 2004, 23:363-65. CrossRef
  30. O'Ryan M, Lucero Y, Pe?a A, Valenzuela MT: Two year review of intestinal intussusception in six large public hospitals of Santiago, Chile. / Pediatr Infect Dis J 2003, 22:717-21. CrossRef
  31. Pérez-Schael I, Escalona M, Salinas B, Materán M, Pérez ME, González G: Intussusception-associated hospitalization among Venezuelan infants during 1998 through 2001: anticipating rotavirus vaccines. / Pediatr Infect Dis J 2003, 22:234-39.
  32. World Health Organization: / Acute intussusception in infants and children, Incidence, clinical presentation and management: a global perspective. [http://www.who.int/vaccines-documents/DocsPDF02/www640.pdf]
  33. Hsu HY, Kao CL, Huang LM, Ni YH, Lai HS, Lin FY, Chang MH: Viral etiology of intussusception in Taiwanese childhood. / Pediatr Infect Dis J 1998, 17:893-98. CrossRef
  34. Bines JE, Liem NT, Justice FA, Son TN, Kirkwood CD, de Campo M, Barnett P, Bishop RF, Robins-Browne R, Carlin JB, Intussusception Study Group: Risk factors for intussusception in infants in Vietnam and Australia: adenovirus implicated, but not rotavirus. / J Pediatr 2006, 149:452-60. CrossRef
  35. Moore FO, Berne JD, Slamon NB, Penfil SH, Dunn SP: Intussusception in a child with respiratory syncytial virus: a new association. / Del Med J 2006, 78:185-87.
  36. Parashar UD, Holman RC, Cummings KC, Staggs NW, Curns AT, Zimmerman CM, Kaufman SF, Lewis JE, Vugia DJ, Powell KE, Glass RI: Trends in intussusception-associated hospitalizations and deaths among US infants. / Pediatrics 2000, 106:1413-421. CrossRef
  37. Pérez-Schael I, González R, Fernández R, Alfonzo E, Inaty D, Boher Y, Sarmiento L: Epidemiological features of rotavirus infection in Caracas, Venezuela: implications for rotavirus immunization programs. / J Med Virol 1999, 59:520-26. CrossRef
  38. Kuppermann N, O'Dea T, Pinckney L, Hoecker C: Predictors of intussusception in young children. / Arch Pediatr Adolesc Med 2000, 154:250-55.
  39. Velázquez FR, Garcia-Lozano H, Rodriguez E, Cervantes Y, Gómez A, Melo M, Anaya L, Ovalle JC, Torres J, Diaz De Jesus B, Alvarez-Lucas C, Breuer T, Mu?oz O, Kuri P: Diarrhea morbidity and mortality in Mexican children: impact of rotavirus disease. / Pediatr Infect Dis J 2004,23(Suppl 10):S149-S155.
  40. Kane EM, Turcios RM, Arvay ML, Garcia S, Bresee JS, Glass RI: The epidemiology of rotavirus diarrhea in Latin America, Anticipating rotavirus vaccines. / Pan Am J Public Health 2004, 16:371-77. CrossRef
  41. O'Ryan M, Pérez-Schael I, Mamani N, Pe?a A, Salinas B, González G, González F, Matson DO, Gómez J: Rotavirus-associated medical visits and hospitalizations in South America: a prospective study at three large sentinel hospitals. / Pediatr Infect Dis J 2001, 20:685-93. CrossRef
  42. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-230X/13/95/prepub
  
• 作者单位：Xavier Sáez-Llorens (31)
  F Raúl Velázquez (29)
  Pio Lopez (30)
  Felix Espinoza (31)
  Alexandre C Linhares (29)
  Hector Abate (30)
  Ernesto Nu?ez (31)
  Guillermo Venegas (31)
  Rodrigo Vergara (29)
  Ana L Jimenez (30)
  Maribel Rivera (31)
  Carlos Aranza (29)
  Vesta Richardson (30) (31)
  Mercedes Macias-Parra (31)
  Guillermo Ruiz Palacios (29)
  Luis Rivera (30)
  Eduardo Ortega-Barria (29) (31)
  Yolanda Cervantes (29)
  Ricardo Rüttimann (30) (30)
  Pilar Rubio (29) (31)
  Camilo J Acosta (29) (31)
  Claire Newbern (29) (30)
  Thomas Verstraeten (30) (30)
  Thomas Breuer (30) (31)
  
  31. GlaxoSmithKline Vaccines, Parc de la Noire Epine, Rue Fleming, Wavre, 20 1300, Belgium
  29. Philadelphia Department of Public Health, Philadelphia, USA
  30. P95 Excellence in Pharmacovigilance and Epidemiology, Koning Leopold III laan 1, Leuven, 3001, Belgium
  

文摘

Background Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotavirus vaccines have now been developed and extensively studied for their potential association with IS. This study aimed to describe the epidemiology and to estimate the incidence of IS in Latin American infants prior to new vaccine introduction. Methods Children under 2 years of age representing potential IS cases were enrolled in 16 centers in 11 Latin American countries from January 2003 to May 2005. IS cases were classified as definite, probable, possible or suspected as stated on the Brighton Collaboration Working Group guidelines. Results From 517 potential cases identified, 476 (92%) cases were classified as definite, 21 probable, 10 possible and 10 suspected for intussusception. Among the 476 definite IS cases, the median age at presentation was 6.4 months with 89% of cases aged <1 year. The male to female ratio was 1.5:1. The incidence of definite IS per 100,000 subject-years ranged from 1.9 in Brazil to 62.4 in Argentina for children <2 years of age, and from 3.8 in Brazil to 105.3 in Argentina for children aged <1 year. Median hospital stay was 4 days with a high prevalence of surgery as the primary treatment (65%). Most cases (88%) made a complete recovery, but 13 (3%) died. No clear seasonal pattern of IS cases emerged. Conclusions This study describes the epidemiology and estimates the incidence of IS in Latin American infants prior to the introduction of new rotavirus vaccines. The incidence of IS was found to vary between different countries, as observed in previous studies. Trial registration Clinical study identifier 999910/204 (SERO-EPI-IS-204)