Acerola (Malpighia emarginata DC.) juice intake protects against alterations to proteins involved in inflammatory and lipolysis pathways in the adipose tissue of obese mice fed a cafeteria diet
详细信息 查看全文
- 作者：Fernando Milanez Dias (2)
Daniela Dimer Leffa (1)
Francine Daumann (1)
Schérolin de Oliveira Marques (2)
Thais F Luciano (2)
Jonathan Correa Possato (2)
Aline Alves de Santana (3)
Rodrigo Xavier Neves (4)
José Cesar Rosa (5)
Lila Missae Oyama (3)
Bruno Rodrigues (6)
Vanessa Moraes de Andrade (1)
Cláudio Teodoro de Souza (2)
Fabio Santos de Lira (7) - 关键词：Cafeteria diet ; Malpighia emarginata DC ; Adipose tissue ; Inflammation ; Lipolysis
- 刊名：Lipids in Health and Disease
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：13
- 期：1
- 全文大小：468 KB
- 参考文献：1. Siriwardhana N, Kalupahana NS, Cekanova M, LeMieux M, Greer B, Moustaid-Moussa N: Modulation of adipose tissue inflammation by bioactive food compounds. / J Nutr Biochem 2013,24(4):613-3. doi: 10.1016/j.jnutbio.2012.12.013 CrossRef
2. Watt MJ, Spriet LL: Triacylglycerol lipases and metabolic control: implications for health and disease. / Am J Physiol Endocrinol Metab 2010, 299:E162-68.
3. Xiao G, Zhang T, Yu S, Lee S, Calabuig-Navarro V, Yamauchi J, Ringquist S, Dong HH: ATF4 Protein Deficiency Protects against High Fructose-induced Hypertriglyceridemia in Mice. / J Biol Chem 2013,288(35):25350-1. CrossRef
4. Ouchi N, Parker JL, Lugus JJ, Walsh K: Adipokines in inflammation and metabolic disease. / Nat Rev Immunol 2011,11(2):85-7. doi: 10.1038/nri2921. Epub 2011 Jan 21. Review CrossRef
5. He J, Gao J, Xu M, Ren S, Stefanovic-Racic M, O'Doherty RM, Xie W: PXR ablation alleviates diet-induced and genetic obesity and insulin resistance in mice. / Diabetes 2013,62(6):1876-7. doi: 10.2337/db12-039. Epub 2013 Jan 24 CrossRef
6. Calder PC, Ahluwalia N, Brouns F, Buetler T, Clement K, Cunningham K, Esposito K, J?nsson LS, Kolb H, Lansink M, Marcos A, Margioris A, Matusheski N, Nordmann H, O'Brien J, Pugliese G, Rizkalla S, Schalkwijk C, Tuomilehto J, W?rnberg J, Watzl B, Winklhofer-Roob BM: Dietary factors and low-grade inflammation in relation to overweight and obesity. / Br J Nutr 2011,106(Suppl 3):S5-8. doi: 10.1017/S0007114511005460. Review CrossRef
7. Cunha CA, Lira FS, Rosa Neto JC, Pimentel GD, Souza GI, da Silva CM, de Souza CT, Ribeiro EB, Sawaya AC, Oller do Nascimento CM, Rodrigues B, de Oliveira Carvalho P, Oyama LM: Green tea extract supplementation induces the lipolytic pathway, attenuates obesity, and reduces low-grade inflammation in mice fed a high-fat diet. / Mediators Inflamm 2013, 2013:635470. CrossRef
8. Barbalho SM, Damasceno DC, Spada AP, Palhares M, Martuchi KA, Oshiiwa M, Sazaki V, da Silva VS: Evaluation of glycemic and lipid profile of offspring of diabetic Wistar rats treated with Malpighia emarginata juice. / Exp Diabetes Res 2011, 2011:173647. doi: 10.1155/2011/173647. Epub 2011 Jan 23 CrossRef
9. Hanamura T, Uchida E, Aoki H: Skin-lightening effect of a polyphenol extract from Acerola (Malpighia emarginata DC.) fruit on UV-induced pigmentation. / Biosci Biotechnol Biochem 2008,72(12):3211-. Epub 2008 Dec 7 CrossRef
10. Ajuwon KM, Spurlock ME: Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3?T3-L1 adipocytes. / J Nutr 2005,135(8):1841-.
11. Lira FS, Rosa JC, Pimentel GD, Seelaender M, Damaso AR, Oyama LM, do Nascimento CO: Both adiponectin and interleukin-10 inhibit LPS-induced activation of the NF-κB pathway in 3T3-L1 adipocytes. / Cytokine 2012,57(1):98-06. doi: 10.1016/j.cyto.2011.10.001. Epub 2011 Nov 1 CrossRef
12. Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Araújo EP, Vassallo J, Curi R, Velloso LA, Saad MJ: Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. / Diabetes 2007,56(8):1986-8. Epub 2007 May 22 CrossRef
13. Feingold KR, Doerrler W, Dinarello CA, Fiers W, Grunfeld C: Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis. / Endocrinology 1992,130(1):10-.
14. Estadella D, da Penha Oller do Nascimento CM, Oyama LM, Ribeiro EB, Damaso AR, de Piano A: Lipotoxicity: effects of dietary saturated and transfatty acids. / Mediators Inflamm. 2013, 2013:137579. CrossRef
15. Suganami T, Nishida J, Ogawa Y: A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. / Arterioscler Thromb Vasc Biol 2005,25(10):2062-. Epub 2005 Aug 25 CrossRef
16. Shafat A, Murray B, Rumsey D: Energy density in cafeteria diet induced hyperphagia in the rat. / Appetite 2009,52(1):34-. doi: 10.1016/j.appet.2008.07.004. Epub 2008 Jul 17 CrossRef
17. Zamboni M, Di Francesco V, Garbin U, Fratta Pasini A, Mazzali G, Stranieri C, Zoico E, Fantin F, Bosello O, Cominacini L: Adiponectin gene expression and adipocyte NF-kappaB transcriptional activity in elderly overweight and obese women: inter-relationships with fat distribution, hs-CRP, leptin and insulin resistance. / Int J Obes (Lond) 2007,31(7):1104-. Epub 2007 Feb 27 CrossRef
18. Campión J, Milagro FI, Fernández D, Martínez JA: Diferential gene expression and adiposity reduction induced by ascorbic acid supplementation in a cafeteria model of obesity. / J Physiol Biochem 2006,62(2):71-0. CrossRef
19. García-Díaz D, Campión J, Milagro FI, Martínez JA: Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers. / Mol Cell Biochem 2007,305(1-):87-4. Epub 2007 Jun 27 CrossRef
20. Garcia-Diaz DF, Campion J, Milagro FI, Paternain L, Solomon A, Martinez JA: Ascorbic acid oral treatment modifies lipolytic response and behavioural activity but not glucocorticoid metabolism in cafeteria diet-fed rats. / Acta Physiol (Oxf) 2009,195(4):449-7. doi: 10.1111/j.1748-716.2008.01942.x. Epub 2008 Nov 25 CrossRef
21. Garcia-Diaz DF, Campion J, Quintero P, Milagro FI, Moreno-Aliaga MJ, Martinez JA: Vitamin C modulates the interaction between adipocytes and macrophages. / Mol Nutr Food Res 2011,55(Suppl 2):S257-3. doi: 10.1002/mnfr.201100296. Epub 2011 Jul 28 CrossRef
22. Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A: Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. / Nature 2011,480(7375):104-. CrossRef
23. Rivera L, Morón R, Sánchez M, Zarzuelo A, Galisteo M: Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. / Obesity (Silver Spring) 2008,16(9):2081-. doi: 10.1038/oby.2008.315 CrossRef
24. Overman A, Chuang CC, McIntosh M: Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media. / Int J Obes (Lond). 2011,35(9):1165-2. doi: 10.1038/ijo.2010.272. Epub 2011 Jan 11 CrossRef
25. Hsu CL, Wu CH, Huang SL, Yen GC: Phenolic compounds rutin and o-coumaric acid ameliorate obesity induced by high-fat diet in rats. / J Agric Food Chem 2009,57(2):425-1. doi: 10.1021/jf802715t CrossRef
26. Gao M, Ma Y, Liu D: Rutin suppresses palmitic acids-triggered inflammation in macrophages and blocks high fat diet-induced obesity and fatty liver in mice. / Pharm Res 2013. [Epub ahead of print]
27. Leffa DD, da Silva J, Daumann F, Dajori AL, Longaretti LM, Damiani AP, de Lira F, Campos F, Ferraz AD, C?rrea DS, de Andrade VM: Corrective effects of acerola (Malpighia emarginata DC.) juice intake on biochemical and genotoxical parameters in mice fed on a high-fat diet. / Mutat Res 2013, S0027-107(13)00194-. doi: 10.1016/j.mrfmmm.2013.11.005. [Epub ahead of print] - 作者单位：Fernando Milanez Dias (2)
Daniela Dimer Leffa (1)
Francine Daumann (1)
Schérolin de Oliveira Marques (2)
Thais F Luciano (2)
Jonathan Correa Possato (2)
Aline Alves de Santana (3)
Rodrigo Xavier Neves (4)
José Cesar Rosa (5)
Lila Missae Oyama (3)
Bruno Rodrigues (6)
Vanessa Moraes de Andrade (1)
Cláudio Teodoro de Souza (2)
Fabio Santos de Lira (7)
2. Laboratory of Exercise Biochemistry and Physiology, Graduate Programme of Health Sciences, Department of Health Sciences, Universidade do Extremo Sul Catarinense, UNESC, 888.06-000, Criciúma, SC, Brazil
1. Laboratory of Molecular and Cellular Biology, Graduate Programme of Health Sciences, Department of Health Sciences, Universidade do Extremo Sul Catarinense, UNESC, 888.06-000, Criciúma, SC, Brazil
3. Departamento de Fisiologia, Disciplina de Fisiologia da Nutri??o, Universidade Federal de S?o Paulo (UNIFESP), 04023-060, S?o Paulo, SP, Brazil
4. Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo (USP), S?o Paulo, Brazil
5. Immunometabolism Research Group, Institute of Biomedical Sciences, University of S?o Paulo (USP), S?o Paulo, Brazil
6. Laboratório do Movimento Humano, Universidade S?o Judas Tadeu, S?o Paulo, SP, Brazil
7. Immunometabolism Research Group, Department of Physical Education, Universidade Estadual Paulista, UNESP, Rua Roberto Simonsen, 305, 19060-900, Presidente Prudente, SP, Brazil - ISSN：1476-511X
文摘
Background Obesity has been studied as a metabolic and an inflammatory disease and is characterized by increases in the production of pro-inflammatory adipokines in the adipose tissue. To elucidate the effects of natural dietary components on the inflammatory and metabolic consequences of obesity, we examined the effects of unripe, ripe and industrial acerola juice (Malpighia emarginata DC.) on the relevant inflammatory and lipolysis proteins in the adipose tissue of mice with cafeteria diet-induced obesity. Materials/methods Two groups of male Swiss mice were fed on a standard diet (STA) or a cafeteria diet (CAF) for 13?weeks. Afterwards, the CAF-fed animals were divided into five subgroups, each of which received a different supplement for one further month (water, unripe acerola juice, ripe acerola juice, industrial acerola juice, or vitamin C) by gavage. Enzyme-linked immunosorbent assays, Western blotting, a colorimetric method and histology were utilized to assess the observed data. Results The CAF water (control obese) group showed a significant increase in their adiposity indices and triacylglycerol levels, in addition to a reduced IL-10/TNF-α ratio in the adipose tissue, compared with the control lean group. In contrast, acerola juice and Vitamin C intake ameliorated the weight gain, reducing the TAG levels and increasing the IL-10/TNF-α ratio in adipose tissue. In addition, acerola juice intake led to reductions both in the level of phosphorylated JNK and to increases in the phosphorylation of IκBα and HSLser660 in adipose tissue. Conclusions Taken together, these results suggest that acerola juice reduces low-grade inflammation and ameliorates obesity-associated defects in the lipolytic processes.