Das Tumorepigenom – von der Genregulation über die Tumorklassifikation zum Therapietarget

详细信息    查看全文

• 作者：Prof. Dr. Ole Ammerpohl ; Martina Deckert ; Manuel Montesinos-Rongen
• 关键词：SchlüsselwörterEpigenetik ; DNA ; Methylierung ; MGMT ; Tumorepigenom
• 刊名：medizinische genetik
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：28
• 期：4
• 页码：424-434
• 全文大小：
• 刊物主题：Reproductive Medicine; Human Genetics; Pediatrics; Obstetrics/Perinatology;
• 出版者：Springer Medizin
• ISSN：1863-5490
• 卷排序：28

文摘

Epigenetic control mechanisms are essential for the coordination of numerous cellular processes, including differentiation and development as well as for the adaptation of gene activity according to environmental conditions. In particular, tumor diseases are often accompanied by comprehensive alterations in the epigenome. These alterations are frequently characteristic either for the tumor entity, the tumor state, the clinical response of the tumor to an anti-cancer therapy or the individual prognosis of the patient. After a brief introduction into epigenetic marks and their impact for cancer, this article will focus on alterations in the tumor epigenome and their value for individualized medicine.