Prenatal Maternal Smoking and Tourette Syndrome: A Nationwide Register Study

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• 作者：Susanna Leivonen ; Roshan Chudal ; Petteri Joelsson…
• 关键词：Tourette syndrome ; Prenatal maternal smoking ; ADHD ; Register study ; Epidemiology ; Risk factor
• 刊名：Child Psychiatry and Human Development
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：47
• 期：1
• 页码：75-82
• 全文大小：378 KB
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• 作者单位：Susanna Leivonen (1) (2)
  Roshan Chudal (1)
  Petteri Joelsson (1)
  Mikael Ekblad (3)
  Auli Suominen (1)
  Alan S. Brown (4) (5)
  Mika Gissler (1) (6) (7)
  Arja Voutilainen (2)
  Andre Sourander (1) (8) (9)
  
  1. Department of Child Psychiatry, University of Turku, Turku, Finland
  2. Child Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
  3. Department of Pediatrics, Turku University Hospital and University of Turku, Turku, Finland
  4. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY, USA
  5. Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY, USA
  6. National Institute of Health and Welfare (THL), Helsinki, Finland
  7. Nordic School of Public Health, Gothenburg, Sweden
  8. Department of Child Psychiatry, Turku University Hospital, Turku, Finland
  9. RKBU, UiT Arctic University in Norway, Tromsø, Norway
  
• 刊物类别：Behavioral Science
• 刊物主题：Psychology
  Child and School Psychology
  Psychiatry
  
• 出版者：Springer Netherlands
• ISSN：1573-3327

文摘

This is the first nationwide register-based study to examine the relationship between prenatal maternal smoking and Tourette syndrome. A total of 767 children diagnosed with Tourette syndrome were identified from the Finnish Hospital Discharge Register. Each case was matched to four controls. Information on maternal smoking during pregnancy was obtained from the Finnish Medical Birth Register. Conditional logistic regression models were used for statistical analyses. Prenatal maternal smoking was associated with Tourette syndrome when comorbid with ADHD (OR 4.0, 95 % CI 1.2–13.5, p = 0.027 for exposure during first trimester, OR 1.7, 95 % CI, 1.05–2.7, p = 0.031 for exposure for the whole pregnancy). There was no association between maternal smoking during pregnancy and Tourette syndrome without comorbid ADHD (OR 0.5, 95 % CI 0.2–1.3, p = 0.166, OR 0.9, 95 % CI 0.7–1.3, p = 0.567). Further research is needed to elucidate the mechanisms behind the association between prenatal maternal smoking and Tourette syndrome with comorbid ADHD. Keywords Tourette syndrome Prenatal maternal smoking ADHD Register study Epidemiology Risk factor