Bipolar disorder and parental psychopathology

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• 作者：Dan Sucksdorff (1)
  Roshan Chudal (1)
  Auli Suominen (1)
  Elina Jokiranta (1)
  Alan S. Brown (2) (3)
  Andre Sourander (1) (2) (4)
  
• 关键词：Bipolar disorder ; Schizophrenia ; Register ; Population ; based study ; Epidemiology ; Parental psychopathology
• 刊名：Social Psychiatry and Psychiatric Epidemiology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：49
• 期：12
• 页码：1973-1984
• 全文大小：222 KB
• 参考文献：1. Chang KD, Steiner H, Ketter TA (2000) Psychiatric phenomenology of child and adolescent bipolar offspring. J Am Acad Child Adolesc Psychiatry 39:453-60 CrossRef
  2. Henin A, Biederman J, Mick E, Sachs GS, Hirschfeld-Becker DR, Siegel RS, McMurrich S, Grandin L, Nierenberg AA (2005) Psychopathology in the offspring of parents with bipolar disorder: a controlled study. Biol Psychiatry 58:554-61 CrossRef
  3. Hirchfeld-Becker DR, Biederman J, Henin A, Faraone SV, Dowd ST, De Petrillo LA, Markowitz SM, Rosenbaum JF (2006) Psychopathology in the young offspring of parents with bipolar disorder: a controlled pilot study. Psychiatry Res 145:155-67 CrossRef
  4. Singh MK, Delbello MP, Stanford KE, Soutullo C, McDonough-Ryan P, McElroy SL, Strakowski SM (2007) Psychopathology in children of bipolar parents. J Affect Disord 102:131-36 CrossRef
  5. NeslihanInal-Eiroglu F, Ozerdem A, Miklowitz D, Baykara A, Akay A (2008) Mood and disruptive behavior disorders and symptoms in the offspring of patients with bipolar I disorder. World Psychiatry 7:110-12
  6. Zappitelli MC, Bordin IA, Hatch JP, Caetano SC, Zunta-Soares G, Olvera RL, Soares JC (2011) Lifetime psychopathology among the offspring of bipolar I parents. Clinics 66:725-30 CrossRef
  7. Lapalme M, Hodgins S, LaRoche C (1997) Children of parents with bipolar disorder: a metaanalysis of risk for mental disorders. Can J Psychiatry 42:623-31
  8. Mortensen PB, Pedersen M, Melbye M, Mors O, Ewald H (2003) Individual and familial risk factors for bipolar affective disorders in Denmark. Arch Gen Psychiatry 60:1209-215 CrossRef
  9. Laursen TM, Labouriau R, Licht RW, Bertelsen A, Munk-Olsen T, Mortensen PB (2005) Family history of psychiatric illness as a risk factor for schizoaffective disorder. Arch Gen Psychiatry 62:841-48 CrossRef
  10. Lichtenstein P, Yip BH, Bj?rk C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM (2009) Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 373:234-39 CrossRef
  11. Dean K, Stevens H, Mortensen PB, Murray RM, Walsh E, Pedersen CB (2010) Full spectrum of psychiatric outcomes among offspring with parental history of mental disorder. Arch Gen Psychiatry 67:822-29 CrossRef
  12. Gottesman II, Laursen TM, Bertelsen A, Mortensen PB (2010) Severe mental disorders in offspring with 2 psychiatrically ill parents. Arch Gen Psychiatry 67:252-57 CrossRef
  13. Helenius D, J?rgensen PM, Steinhausen HC (2013) A three generations nation-wide population study of family load estimates in bipolar disorder with different age at onset. J Affect Disord 150:146-51 CrossRef
  14. Castagnini AC, Laursen TM, Mortensen PB, Bertelsen A (2013) Family psychiatric morbidity of acute and transient psychotic disorders and their relationship to schizophrenia and bipolar disorder. Psychol Med 43:2369-375 CrossRef
  15. Chudal R, Sucksdorff D, Suominen A, Lehti V, Hinkka-Yli-Salom?ki S, Huttunen J, Ristkari T, Gissler M, McKeague IW, Brown AS, Sourander A (2013) Finnish prenatal study of bipolar disorders (FIPS-B): overview, design and description of the sample. Nord J Psychiatry. doi:10.3109/08039488.2013.789073
  16. Larsson HJ, Eaton WW, Madsen KM, Vestergaard M, Olesen AV, Agerbo E, Schendel D, Thorsen P, Mortensen PB (2005) Risk factors for autism: perinatal factors, parental psychiatric history and socioeconomic status
• 作者单位：Dan Sucksdorff (1)
  Roshan Chudal (1)
  Auli Suominen (1)
  Elina Jokiranta (1)
  Alan S. Brown (2) (3)
  Andre Sourander (1) (2) (4)
  
  1. Department of Child Psychiatry, Faculty of Medicine, Research Centre for Child Psychiatry, Institute of Clinical Medicine, University of Turku, Lemmink?isenkatu 3/Teutori (3rd floor), 20014, Turku, Finland
  2. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, USA
  3. Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, USA
  4. Department of Child Psychiatry, Turku University Hospital, Turku, Finland
  
• ISSN：1433-9285

文摘

Purpose Few population-based studies have examined the association between parental psychopathology and bipolar disorder (BPD) in offspring. One limitation is lack of control for potential confounding by indicators of parental socio-economic status or maternal smoking during pregnancy. Furthermore, none of them included analyses restricted to parental diagnoses received prior to the birth of the offspring. Associations could not be affected by child-related factors affecting the parent in such analyses. This study explores associations between those parental psychiatric disorders diagnosed at any point of time as well as those diagnosed before offspring birth, and BPD in offspring. Methods In this nested case–control study, we identified 1,861 cases, age up to 25?years, 3,643 matched controls, and their parents from Finnish national registers. The associations were examined using conditional logistic regression, calculating odds ratios (OR) and adjusting for region of birth, parental age and education and mother’s smoking during pregnancy. Results Anytime diagnosed parental disorders associating with BPD in offspring (95?% confidence interval) were BPD [OR (maternal) 5.2 (2.52-0.62); OR (paternal) 8.1 (3.77-7.26)], schizophrenia and related psychoses [OR (maternal) 3.1 (1.69-.84); OR (paternal) 4.5 (1.97-0.27)], other affective disorders [OR (maternal) 3.0 (2.08-.21); OR (paternal) 3.0 (1.97-.47)] and maternal anxiety disorders OR 2.6 (1.08-.42). Statistically significant associations were also found for parental schizophrenia and related psychoses, and other affective disorders, diagnosed before offspring birth. Conclusions BPD is associated with many parental psychiatric disorders, particularly BPD and schizophrenia and related psychoses. The associations must be partially due to child-independent factors. Covariate adjustments had only a minor impact on the associations.