Apolipoprotein E polymorphism in patients with neuropsychiatric SLE
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- 作者：Rudolf Pullmann ; M¨¢ria ?kere¨¾ov¨¢ ; Jana Hybenov¨¢ ; Jozef Luk¨¢? ; Jozef Rovensky and Rudolf Pullmann
- 关键词：Apolipoprotein E ; Neuropsychiatric SLE ; Polymorphism
- 刊名：Clinical Rheumatology
- 出版年：2004
- 出版时间：April 2004
- 年：2004
- 卷：23
- 期：2
- 页码：97-101
- 全文大小：188 KB
文摘
The aim of this study was to investigate a relationship between neuropsychiatric SLE (NPSLE), characterized by many different neurological and psychiatric disorders, and the polymorphism of apoE as a neurobiologically important molecule conferring increased risk and a worse prognosis of a variety of CNS diseases. One hundred and forty-six SLE patients and 93 healthy controls were studied. Out of the SLE cohort, 48 patients (32.8 % ) were diagnosed with NPSLE and further classified according to criteria of onset, extent, relapsing tendency and type of neuropsychiatric impairment. Apolipoprotein E (apoE) polymorphism was determined by PCR-RFLP and confirmed by isoelectrofocusing. The frequency of the 4 allele was significantly higher in the NPSLE group than in the non-NPSLE group (17.7 % vs. 3.1 % , 2=19.05, p<0.0001). Distribution of apoE genotypes was significantly different between NPSLE and non-NPSLE groups (2=80.95, p<0.0001). Both 4 allele frequency (17.7 % vs 8.6 % , 2=5.082, p<0.024) and genotype distribution (2=7.202, p<0.027) were significantly different between NPSLE group and the controls. The allele 4 was also associated with earlier disease onset (Fishers test, p<0.036) and peripheral nervous system involvement (2=8.242, p<0.0041), but not with relapse frequency (p<0.37) or major/minor subtype of the disease (p<0.90). The 4 allele carriers did not develop significantly more neuropsychiatric syndromes than non- carriers (1.75±0.23 sy (mean ± SD) in 4 vs 1.85±0.19 sy (mean ± SD) in non-4 carriers, Mann–Whitney test, p<0.78). In conclusion, the data suggest an association between apoE polymorphism and NPSLE.