Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival
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- 作者：Carolina Alvarez ; Andrés Aravena ; Teresa Tapia ; Ester Rozenblum ; Luisa Solís…
- 关键词：Breast cancer ; BRCAX ; Array CGH ; Tumor suppressor ; Oncogenes ; Genomic losses ; Genomic gains
- 刊名：BMC Cancer
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：16
- 期：1
- 全文大小：1,546 KB
- 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2407
文摘
Background Array CGH analysis of breast tumors has contributed to the identification of different genomic profiles in these tumors. Loss of DNA repair by BRCA1 functional deficiency in breast cancer has been proposed as a relevant contribution to breast cancer progression for tumors with no germline mutation. Identifying the genomic alterations taking place in BRCA1 not expressing tumors will lead us to a better understanding of the cellular functions affected in this heterogeneous disease. Moreover, specific genomic alterations may contribute to the identification of potential therapeutic targets and offer a more personalized treatment to breast cancer patients.