Naphthopyrone glucosides from the seeds ofCassia tora with inhibitory activity on advanced glycation end products (AGEs) formation

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• 作者：Ga Young Lee (1)
  Dae Sik Jang (1)
  Yun Mi Lee (1)
  Jong Min Kim (1)
  Jin Sook Kim (1)
  
• 关键词：Cassia tora ; Leguminosae ; Cassiaside ; Rubrofusarin ; 6 ; O ; β ; D ; gentiobioside ; Toralactone ; 9 ; O ; β ; D ; gentiobioside ; Advanced glycation end products (AGEs) ; Diabetic complications
• 刊名：Archives of Pharmacal Research
• 出版年：2006
• 出版时间：July 2006
• 年：2006
• 卷：29
• 期：7
• 页码：587-590
• 全文大小：343KB
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• 作者单位：Ga Young Lee (1)
  Dae Sik Jang (1)
  Yun Mi Lee (1)
  Jong Min Kim (1)
  Jin Sook Kim (1)
  
  1. Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, 461-24 Jeonmin-dong, Yuseong-gu, 305-811, Daejeon, Korea
  
• ISSN：1976-3786

文摘

Three naphthopyrone glucosides, cassiaside (1), rubrofusarin-6-O-β-D-gentiobioside (2), and toralactone-9-O-β-D-gentiobioside (3), were isolated from the BuOH-soluble extract of the seeds ofCassia tora as active constituents, using an,in vitro bioassay based on the inhibition of advanced glycation end products (AGEs) to monitor chromatographic fractionation. The structures of1- were determined by spectroscopic data interpretation, particularly by extensive 1D and 2D NMR studies. All the isolates (1-) were evaluated for the inhibitory activity on AGEs formationin vitro.