Interleukin 15 receptor alpha rs2228059 A > C polymorphism decreased risk of gastric cardiac adenocarcinoma in a Chinese population

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• 作者：Jun Yin (1)
  Chao Liu (1)
  Xu Wang (1)
  Liming Wang (2)
  Yijun Shi (1)
  Weifeng Tang (1)
  Guowen Ding (1)
  Ruiping Liu (3)
  Suocheng Chen (1)
  Haiyong Gu (1)
  Liang Zheng (4)
  
• 关键词：IL15RA ; Polymorphisms ; Gastric cardiac adenocarcinoma ; Molecular epidemiology
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：35
• 期：7
• 页码：6593-6600
• 全文大小：681 KB
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• 作者单位：Jun Yin (1)
  Chao Liu (1)
  Xu Wang (1)
  Liming Wang (2)
  Yijun Shi (1)
  Weifeng Tang (1)
  Guowen Ding (1)
  Ruiping Liu (3)
  Suocheng Chen (1)
  Haiyong Gu (1)
  Liang Zheng (4)
  
  1. Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 212002, China
  2. Cancer Institute, Department of Chemotherapy, People’s Hospital Affiliated to Jiangsu University, Zhenjiang, Jiangsu, 212002, China
  3. Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People’s Hospital, Changzhou, 213003, China
  4. Department of Cardiothoracic Surgery, The First People’s Hospital of Changzhou and The Third Affiliated Hospital of Suzhou University, Changzhou, 213003, China
  
• ISSN：1423-0380

文摘

Gastric cardiac adenocarcinoma (GCA) is one of the common malignant tumors in the world and has a high incidence in China. Both environmental risk factors and genetic factors might play an essential role in the GCA carcinogenesis. We performed a hospital-based case–control study to evaluate the genetic effects of interleukin 15 (IL15) and IL15 receptor alpha (IL15RA) functional single nucleotide polymorphisms (SNPs) on the pathogenesis of GCA. A total of 243 GCA cases and 476 controls were enrolled in this study. The genotypes were determined using a custom-by-design 48-Plex SNPscanTM Kit. When the IL15RA rs2228059 AA homozygote genotype was used as the reference group, the CC genotype was correlated with a significantly decreased risk for GCA (CC vs. AA: adjusted OR--.61, 95?% CI--.37-.98, p--.042). Our results revealed that functional variant IL15RA rs2228059 A-?C might attenuate individual’s risk of GCA. However, there was no significant association between the other five IL15 SNPs and GCA susceptibility. This present study demonstrated that IL15RA rs2228059 A-?C polymorphism might modify GCA susceptibility. The results were based on a limited sample size; future larger studies with more rigorous designs are warranted to validate our findings.