Neural fate decisions mediated by combinatorial regulation of Hes1 and miR-9

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• 作者：Shanshan Li ; Yanwei Liu ; Zengrong Liu ; Ruiqi Wang
• 关键词：Neural fate decision ; Hes1 ; miR ; 9 ; Oscillation ; Bifurcation
• 刊名：Journal of Biological Physics
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：42
• 期：1
• 页码：53-68
• 全文大小：1,220 KB
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• 作者单位：Shanshan Li (1)
  Yanwei Liu (2)
  Zengrong Liu (1)
  Ruiqi Wang (2)
  
  1. Institute of Systems Biology, Shanghai University, Shanghai, China
  2. Department of Mathematics, Shanghai University, Shanghai, China
  
• 刊物类别：Physics and Astronomy
• 刊物主题：Physics
  Biophysics and Biomedical Physics
  Condensed Matter
  Statistical Physics
  Polymer Sciences
  Bioinformatics
  Neurosciences
  
• 出版者：Springer Netherlands
• ISSN：1573-0689

文摘

In the nervous system, Hes1 shows an oscillatory manner in neural progenitors but a persistent one in neurons. Many models involving Hes1 have been provided for the study of neural differentiation but few of them take the role of microRNA into account. It is known that a microRNA, miR-9, plays crucial roles in modulating Hes1 oscillations. However, the roles of miR-9 in controlling Hes1 oscillations and inducing transition between different cell fates still need to be further explored. Here we provide a mathematical model to show the interaction between miR-9 and Hes1, with the aim of understanding how the Hes1 oscillations are produced, how they are controlled, and further, how they are terminated. Based on the experimental findings, the model demonstrates the essential roles of Hes1 and miR-9 in regulating the dynamics of the system. In particular, the model suggests that the balance between miR-9 and Hes1 plays important roles in the choice between progenitor maintenance and neural differentiation. In addition, the synergistic (or antagonistic) effects of several important regulations are investigated so as to elucidate the effects of combinatorial regulation in neural decision-making. Our model provides a qualitative mechanism for understanding the process in neural fate decisions regulated by Hes1 and miR-9. Keywords Neural fate decision Hes1 miR-9 Oscillation Bifurcation