Effect of low-level laser therapy on bone repair: a randomized controlled experimental study

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• 作者：Valéria Regina Gonzalez Sella ; Fernando Russo Costa do Bomfim…
• 关键词：Bone remodeling ; Femoral fracture ; Low ; level laser therapy
• 刊名：Lasers in Medical Science
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：30
• 期：3
• 页码：1061-1068
• 全文大小：1,441 KB
• 参考文献：1. Oliveira, AM, Castro-Silva, II, Fernandes, GVO, Melo, BR, Alves, ATNN, Júnior, AS, Lima, ICB, Granjeiro, JM (2014) Effectiveness and acceleration os bone repair in critical-sized rat calvarial defects using low-level laser therapy. Laser Surg Med 46: pp. 61-67 CrossRef
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Medicine/Public Health, general
  Dentistry
  Laser Technology and Physics and Photonics
  Quantum Optics, Quantum Electronics and Nonlinear Optics
  Applied Optics, Optoelectronics and Optical Devices
  
• 出版者：Springer London
• ISSN：1435-604X

文摘

The aim of this study was to investigate the effect of low-level laser therapy (LLLT) on bone repair in femoral fractures. Sixty adult Wistar rats were randomly assigned into one of two groups: group A (ostectomy + LLLT) or group B (ostectomy + sham laser). An experimental model of complete bone fracture was surgically created by removing a 2-mm fragment from the middle third of the femoral shaft. Data were analyzed on days 8, 13, and 18 after the fracture (subgroups 1, 2, and 3). Samples were assessed for changes in inflammatory infiltration; trabecular bone matrix, periosteal, and new bone formations; and changes in the expression of particular osteogenic-related proteins (osteocalcin, osteopontin, and osteonectin). Microscopic analysis revealed a significant decrease in inflammatory infiltration, intense trabecular bone matrix and periosteal formation, and an increase in newly formed bone after laser irradiation. We also found an increase in the expression of bone matrix proteins with LLLT, with a significant difference measured for osteocalcin in the LLLT group at day 8 (p--.007). We show that LLLT plays an important role in augmenting bone tissue formation, which is relevant to fracture healing. LLLT may therefore be indicated as an adjunct therapeutic tool in clinical practice for the treatment or recovery of nonunion injuries.