Spinal autophagy is differently modulated in distinct mouse models of neuropathic pain
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- 作者：Laura Berliocchi ; Maria Maiarù ; Giuseppe Pasquale Varano ; Rossella Russo…
- 关键词：Spinal nerve ligation ; Chronic constriction injury ; Spared nerve injury ; Neuropathic pain ; Autophagy ; LC3 ; SQSTM1/p62 ; Beclin 1 ; Chloroquine
- 刊名：Molecular Pain
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：11
- 期：1
- 全文大小：1,607 KB
- 刊物主题：Pain Medicine; Molecular Medicine;
- 出版者：BioMed Central
- ISSN：1744-8069
文摘
Background Autophagy is a homeostatic degradative process essential for basal turnover of long-lived proteins and organelles as well as for removal of dysfunctional cellular components. Dysregulation of the autophagic machinery has been recently associated to several conditions including neurodegenerative diseases and cancer, but only very few studies have investigated its role in pain processing.