Distribution and pharmacokinetics of dinitrosyl iron complexes in rat organs

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• 作者：A. A. Timoshin (1)
  V. L. Lakomkin (1)
  E. K. Ruuge (1)
  A. F. Vanin (2)
  
• 关键词：Oxacom ; hypotensive effect ; DNIC ; NO donor ; S ; nitrosothiols ; spin trap ; EPR
• 刊名：Biophysics
• 出版年：2012
• 出版时间：March 2012
• 年：2012
• 卷：57
• 期：2
• 页码：233-236
• 全文大小：160KB
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• 作者单位：A. A. Timoshin (1)
  V. L. Lakomkin (1)
  E. K. Ruuge (1)
  A. F. Vanin (2)
  
  1. Russian Cardiology Research Center, Moscow, 121552, Russia
  2. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, 119991, Russia
  
• ISSN：1555-6654

文摘

Dinitrosyl iron complexes (DNICs) have been traced in rat blood and organs after intravenous infusion of Oxacom. It is shown that the active principle (DNIC with glutathione) is rapidly distributed through the organism and deposited in blood and organs as protein-bound DNICs. The specific levels of DNIC in the main body organs are comparable, whereas its apparent lifetimes relate as blood < heart = lung < liver < kidney. Spin trapping assays indicate that protein-bound DNICs are a major but not the only form of NO deposition; the next largest depot is most probably formed by S-nitrosothiols. The gradual release of NO from such pools ensures the smooth and prolonged hypotensive effect of Oxacom.