Impact of 900?MHz electromagnetic field exposure on main male reproductive hormone levels: a Rattus norvegicus model
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- 作者：Masood Sepehrimanesh (1)
Mehdi Saeb (1)
Saeed Nazifi (2)
Nasrin Kazemipour (1)
Gholamali Jelodar (3)
Saeedeh Saeb (4) - 关键词：GSM ; Testosterone ; Inhibin B ; Activin B ; Electromagnetic field ; Leydig cells ; Sertoli cells
- 刊名：International Journal of Biometeorology
- 出版年：2014
- 出版时间：September 2014
- 年：2014
- 卷：58
- 期：7
- 页码：1657-1663
- 全文大小：1,166 KB
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Mehdi Saeb (1)
Saeed Nazifi (2)
Nasrin Kazemipour (1)
Gholamali Jelodar (3)
Saeedeh Saeb (4)
1. Department of Biochemistry, School of Veterinary Medicine, Shiraz University, P.O. Box 71345-1731, Shiraz, Iran
2. Department of Clinical Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
3. Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
4. Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran - ISSN：1432-1254
文摘
This work analyzes the effects of radiofrequency-electromagnetic field (RF-EMF) exposure on the reproductive system of male rats, assessed by measuring circulating levels of FSH, LH, inhibin B, activin B, prolactin, and testosterone. Twenty adult male Sprague–Dawley rats (180?±-0?g) were exposed to 900?MHz RF-EMF in four equal separated groups. The duration of exposure was 1, 2, and 4?h/day over a period of 30?days and sham-exposed animals were kept under the same environmental conditions as the exposed group except with no RF-EMF exposure. Before the exposure, at 15 and 30?days of exposure, determination of the abovementioned hormone levels was performed using ELISA. At the end of the experiment, FSH and LH values of the long time exposure (LTE) group were significantly higher than the sham-exposed group (p--.05). Serum activin B and prolactin in the LTE group showed significant increase and inhibin B showed significant decrease than sham and short time exposed (STE) groups after 30?days RF-EMF exposure (p--.05). Also, a significant decrease in serum testosterone levels in the LTE group was found compared to short and moderate time exposed (MTE) groups after 30?days RF-EMF exposure (p--.05). Results suggest that reproductive hormone levels are disturbed as a result of RF-EMF exposure and it may possibly affect reproductive functions. However, testosterone and inhibin B concentrations as a fertility marker and spermatogenesis were decreased significantly.