Psychometric validation of the functional assessment of cancer therapy—brain (FACT-Br) for assessing quality of life in patients with brain metastases

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• 作者：Nemica Thavarajah (1)
  Gillian Bedard (1)
  Liying Zhang (1)
  David Cella (2)
  Jennifer L. Beaumont (2)
  May Tsao (1)
  Elizabeth Barnes (1)
  Cyril Danjoux (1)
  Arjun Sahgal (1)
  Hany Soliman (1)
  Edward Chow (1) (3)
  
• 关键词：Quality of life ; Brain metastases ; Questionnaire ; Psychometric validation ; FACT ; Br ; FACT ; G ; Field ; testing
• 刊名：Supportive Care in Cancer
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：22
• 期：4
• 页码：1017-1028
• 全文大小：389 KB
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• 作者单位：Nemica Thavarajah (1)
  Gillian Bedard (1)
  Liying Zhang (1)
  David Cella (2)
  Jennifer L. Beaumont (2)
  May Tsao (1)
  Elizabeth Barnes (1)
  Cyril Danjoux (1)
  Arjun Sahgal (1)
  Hany Soliman (1)
  Edward Chow (1) (3)
  
  1. Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
  2. Northwestern University, Chicago, IL, USA
  3. Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada, M4N3M5
  
• ISSN：1433-7339

文摘

Objective This study aimed to test the reliability, psychometric, and clinical validity of the use of the Functional Assessment of Cancer Therapy—Brain (FACT-Br) in patients with brain metastases. Methods Patients with brain metastases were interviewed using the FACT-Br (including the FACT-general) 1?week prior to treatment. All patients completed a follow-up assessment 1?month post-treatment. Patients with a good performance status and receiving stereotactic radiosurgery completed an additional 1?week follow-up assessment after the initial baseline interview to assess test–retest reliability. Results Forty patients had complete 1?month follow-up data. Ten of these patients also completed the 1?week follow-up assessment from baseline. The median Karnofsky performance status of patients was 80 and the median age was 64?years. All subscales of the FACT-Br were found to be conceptually related (except for two correlations) using the following subscales: physical well-being (PWB), social/family well-being (SWB), emotional well-being (EWB), functional well-being (FWB), FACT-G total score, brain cancer subscale (BrC), and the FACT-Br total score. All FACT-Br scores demonstrated excellent reliability, except for the SWB scale which revealed good reliability. The FACT-Br scores showed no significant change in the quality of life (QoL) of patients from baseline to 1?month follow-up. Conclusion The use of the combined FACT-G and FACT-Br Subscale to assess QoL specifically in patients with brain metastases has successfully undergone psychometric validation. Future clinical trials should use the FACT-G and FACT-Br Subscale to assess QoL in this patient population.