Association Between Alzheimer’s Disease and the NOS3 gene Glu298Asp Polymorphism in Chinese

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• 作者：Binbin Wang (1) (4)
  Sainan Tan (1) (4)
  Ze Yang (2)
  Yan-Chen Xie (3)
  Jing Wang (1) (4)
  Sirui Zhou (1) (4)
  Shu Li (2)
  Chenguang Zheng (5)
  Xu Ma (1) (4) (6)
  
• 关键词：Late ; onset Alzheimer’s disease ; Endothelial nitric oxide synthase ; NOS3 ; Apolipoprotein E ; Polymorphism ; Chinese
• 刊名：Journal of Molecular Neuroscience
• 出版年：2008
• 出版时间：February 2008
• 年：2008
• 卷：34
• 期：2
• 页码：173-176
• 全文大小：93KB
• 参考文献：1. Akomolafe, A., Lunetta, K. L., Erlich, P. M., Cupples, L. A., Baldwin, C. T., Huyck, M., et al. (2006). Genetic association between endothelial nitric oxide synthase and Alzheimer disease. / Clinical Genetics, / 70, 49-6. CrossRef
  2. American Psychiatric Association (1994). / Diagnostic and staistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.
  3. Blacker, D., Haines, J. L., Rodes, L., Terwedow, H., Go, R. C. P., Harrell, L. E., et al. (1997). ApoE-4 and age of onset of Alzheimer’s disease: the NIMH genetics initiative. / Neurology, / 48, 139-47.
  4. Dahiyat, M., Cumming, A., Harrington, C., Wischik, C., Xuereb, J., Corrigan, F., Breen, G., Shaw, D., & St Clair, D. (1999). Association between Alzheimer’s disease and the NOS3 gene. / Annals of Neurology, / 46, 664-67. CrossRef
  5. Galbusera, C., Facheris, M., Magni, F., et al. (2004). Increased susceptibility to plasma lipid peroxidation in Alzheimer disease patients. / Current Alzheimer Research, / 1, 103-09. CrossRef
  6. Guidi, I., Galimberti, D., Venturelli, E., Lovati, C., Del Bo, R., Fenoglio, C., et al. (2005). Influence of the Glu298Asp polymorphism of NOS3 on age at onset and homocysteine levels in AD patients. / Neurobiology of Aging, / 26, 789-94. CrossRef
  7. Hu, X. F., Zhang, X. R., Xuan, A., & Cao, X. R. (2002). Association between Apolipoprotein E gene polymorphism and the patients with persistent vegetative state in the Chinese. / Acta Genetica Sinica, / 29, 757-60.
  8. Kálmán, J., Juhász, A., Rimanóczy, A., Palotás, A., Palotás, M., Boda, K., et al. (2003). The nitric oxide synthase-3 codon 298 polymorphism is not associated with late-onset sporadic Alzheimer’s dementia and Lewy body disease in a sample from Hungary. / Psychiatric Genetics, / 13, 201-04. CrossRef
  9. Kunugi, H., Akahane, A., Ueki, A., Otsuka, M., Isse, K., Hirasawa, H., Kato, N., Nabika, T., Kobayashi, S., & Nanko, S. (2000). No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer’s disease. / Journal of Neural Transmission, / 107, 1081-084. CrossRef
  10. McKhann, G., Drachman, D., Folstein, M., Datzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS–ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. / Neurology, / 34, 939-44.
  11. Monastero, R., Cefalù, A. B., Camarda, C., Buglino, C. M., Mannino, M., Barbagallo, C. M., et al. (2003). No association between Glu298Asp endothelial nitric oxide synthase polymorphism and Italian sporadic Alzheimer’s disease. / Neurosci Letters, / 341, 229-32. CrossRef
  12. Ntais, C., & Polycarpou, A. (2005). Association of the endothelial nitric oxide synthase (NOS3) Glu298Asp gene polymorphism with the risk of Alzheimer’s disease—a meta-analysis. / Journal De Neurologie, / 252, 1276-278. CrossRef
  13. Sánchez-Guerra, M., Combarros, O., Alvarez-Arcaya, A., Mateo, I., Berciano, J., González-García, J., & Llorca, J. (2001). The Glu298Asp polymorphism in the NOS3 gene is not associated with sporadic Alzheimer’s disease. / Journal of Neurology, Neurosurgery and Psychiatry, / 70, 566-67. CrossRef
  14. Singleton, A. B., Gibson, A. M., McKeith, I. G., Ballard, C. G., Edwardson, J. A., & Morris, C. M. (2001). Nitric oxide synthase gene polymorphisms in Alzheimer’s disease and dementia with Lewy bodies. / Neuroscience Letters, / 303, 33-6. CrossRef
  15. Tedde, A., Nacmias, B., Cellini, E., Bagnoli, S., & Sorbi, S. (2002). Lack of association between NOS3 polymorphism and Italian sporadic and familial Alzheimer’s disease. / Journal de Neurologie, / 249, 110-11. CrossRef
  16. Wang, X. L., Mahaney, M. C., Sim, A. S., Wang, J., Wang, J., Blaugers, J., et al. (1997). Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels. / Arteriosclerosis, Thrombosis, and Vascular Biology, / 17, 3147-153.
  17. Wang, X. L., Sim, A. S., Wang, M. X., Murrell, G. A., Trudinger, B., & Wang, J. (2000). Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity. / FEBS Letters, / 471, 45-0. CrossRef
  18. Wang, Q. H., Zhang, J. W., Zhang, Z. X., Wu, C. B., & Chen, D. (2004). Association between Alzheimer’s disease and nitric oxide synthase III polymorphism. / Zhongguo Yi Xue Ke Xue Yuan Xue Bao, / 26, 112-15.
  19. Veldman, B. A., Spiering, W., Doevendans, P. A., Veervort, G., Kroon, A. A., de Leeuw, P. W., et al. (2002). The Glu298Asp polymorphism of the / NOS3 gene as a determinant of the baseline production of nitric oxide. / Journal of Hypertension, / 20, 2023-027. CrossRef
  20. Yoshimura, M., Yasue, H., Nakayama, M., Shimasaki, Y., Sumida, H., Sugiyama, S., et al. (1998). A missense glu298asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese. / Human Genetics, / 103, 65-9. CrossRef
  
• 作者单位：Binbin Wang (1) (4)
  Sainan Tan (1) (4)
  Ze Yang (2)
  Yan-Chen Xie (3)
  Jing Wang (1) (4)
  Sirui Zhou (1) (4)
  Shu Li (2)
  Chenguang Zheng (5)
  Xu Ma (1) (4) (6)
  
  1. Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing, 100081, China
  4. Peking Union Medical College, Beijing, China
  2. Laboratory for Medical Genetics, Institute of Geriatrics, Beijing Hospital, Ministry of Health, Beijing, 100730, China
  3. Department of Neurology, Beijing Friendship Hospital, Affiliate of Capital University of Medical Sciences, Beijing, 100050, China
  5. Jiangbin Hospital, Nanning, Guangxi, 530021, China
  6. World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China
  

文摘

The oxidative stress caused by nitric oxide (NO) in the brain has been proposed as a pathogenic mechanism in Alzheimer’s disease. Endothelial NO synthase (ecNOS) produces the majority of circulating NO. The biological functional and genetic association studies suggested that the Glu298Asp polymorphism of the ecNOS gene (NOS3) may be a genetic risk factor for late-onset Alzheimer’s disease (LOAD). To investigate an association between the NOS31 Glu298Asp polymorphism and sporadic LOAD in Chinese, we examined 338 LOAD patients and 378 healthy controls. The associations of the Glu/Glu genotype and Glu allele with LOAD (χ 2--.12, df--, P--.003 by genotype; χ 2--.37, df--, P--.038 by allele) were found. After stratifying by apolipoprotein E allele 4 (APOE ?4) status, increased LOAD risks associated with the Glu/Glu genotype and Glu allele only in the APOE ?4 noncarriers (χ 2--.28, df--, P--.012 by genotype; χ 2--.62, df--, P--.018 by allele) were seen. These results suggest that the NOS3 gene Glu298Asp polymorphism might be a risk factor for LOAD and dependent on APOE ?4 status in Chinese.