Radiosynthesis and in vivo evaluation of [125I]2-(4-iodophenethyl)-2-methylmalonic acid as a potential radiotracer for detection of apoptosis

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• 作者：Jongho Jeon ; Ha Eun Shim ; Sajid Mushtaq…
• 关键词：125I ; Radiotracer ; Apoptosis ; SPECT/CT ; Biodistribution
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：308
• 期：1
• 页码：23-29
• 全文大小：608 KB
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• 作者单位：Jongho Jeon (1)
  Ha Eun Shim (1)
  Sajid Mushtaq (1) (2)
  Jung Ae Kang (1)
  You Ree Nam (1)
  Seonhye Yoon (1)
  Hye Rim Kim (1)
  Dae Seong Choi (1)
  Beom Su Jang (1) (2)
  Sang Hyun Park (1) (2)
  
  1. Division for Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk, Korea
  2. Department of Radiation Biotechnology and Applied Radioisotope Science, Korea University of Science and Technology, Daejeon, 305-350, Republic of Korea
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nuclear Chemistry
  Physical Chemistry
  Nuclear Physics, Heavy Ions and Hadrons
  Diagnostic Radiology
  Inorganic Chemistry
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1588-2780

文摘

The aim of this study is to synthesize 125I-labeled 2-(4-iodophenethyl)-2-methylmalonic acid ([125I]IMA) for the development of new apoptosis imaging tracer. The optimized radiolabeling procedure provided [125I]IMA with high radiochemical yield (75.5 ± 5.2 %) and radiochemical purity (>99 %) within 100 min. Specific radioactivity of [125I]IMA was 31.0 MBq/μmol. Biodistribution study of [125I]IMA was carried out using ICR mouse and the result showed the uptake values in apoptotic cells of the testes of the male mice were 1.7–3.2 fold higher than those of leg muscle. Therefore, [125I]IMA will be a promising radiotracer for in vivo SPECT imaging of apoptotic cells.