Mutation profile of EGFR gene detected by denaturing high-performance liquid chromatography in Japanese lung cancer patients

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• 作者：Naoko Sueoka ; Akemi Sato ; Hidetaka Eguchi ; Kazutoshi Komiya ; Toru Sakuragi ; Masahiro Mitsuoka ; Toshimi Satoh ; Shinichiro Hayashi ; Kei Nakachi and Eisaburo Sueoka
• 关键词：Lung cancer ; EGFR mutation ; DHPLC ; BAC
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2007
• 出版时间：February, 2007
• 年：2007
• 卷：133
• 期：2
• 页码：93-102
• 全文大小：525 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Internal Medicine
  Hematology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1335

文摘

Purpose EGFR mutations in lung cancer increase sensitivity to an EGFR tyrosine kinase inhibitor, gefitinib. Mutation analysis of EGFR is essential for prediction of gefitinib response and avoidance of the coincidental severe side effects for the unresponsive population. The purpose of the present study is to apply DHPLC as a screening system of detection of EGFR mutations for large scaled population.