A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: the J-MICC Study

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• 作者：Sakurako Katsuura-Kamano ; Hirokazu Uemura ; Kokichi Arisawa ; Miwa Yamaguchi…
• 关键词：MC4R ; Polymorphism ; Triglycerides ; Body mass index
• 刊名：Endocrine
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：47
• 期：1
• 页码：81-89
• 全文大小：220 KB
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• 作者单位：Sakurako Katsuura-Kamano (1)
  Hirokazu Uemura (1)
  Kokichi Arisawa (1)
  Miwa Yamaguchi (1)
  Nobuyuki Hamajima (2)
  Kenji Wakai (3)
  Rieko Okada (3)
  Sadao Suzuki (4)
  Naoto Taguchi (5)
  Yoshikuni Kita (6)
  Keizo Ohnaka (7)
  Tara Sefanya Kairupan (8)
  Daisuke Matsui (9)
  Isao Oze (10)
  Haruo Mikami (11)
  Michiaki Kubo (12)
  Hideo Tanaka (10)
  
  1. Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima, Japan
  2. Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
  3. Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
  4. Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  5. Department of Preventive Medicine Faculty of Medicine, Saga University, Saga, Japan
  6. Department of Health Science, Shiga University of Medical Science, Otsu, Japan
  7. Department of Geriatric Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
  8. Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan
  9. Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
  10. Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
  11. Division of Cancer Registry, Prevention and Epidemiology, Chiba Cancer Center, Chiba, Japan
  12. Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Yokohama, Japan
  
• ISSN：1559-0100

文摘

Previously reported associations of a common polymorphism near melanocortin-4 receptor (MC4R) gene (rs17782313) with BMI/obesity were inconsistent, especially in East Asia, and the associations of the polymorphism with serum lipid levels have not been fully elucidated. This study evaluated the association between rs17782313 and obesity-related traits and serum lipid levels in the general Japanese population. A total of 2,035 subjects (aged 35-9?years, 1,024 males and 1,011 females) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We examined the associations between near MC4R polymorphism (rs17782313) and obesity-related traits [height, weight, body mass index (BMI), weight change from 20?years old], serum lipid levels (triglycerides, total and HDL-cholesterol), and intake of nutrients (total energy and macronutrients). Polymorphism of rs17782313 (minor C allele) was positively associated with serum triglyceride levels (P for trend?=?0.020) adjusted for age and sex. Analysis using a general linear model revealed that the number of minor C alleles was positively associated with serum triglyceride levels after adjustment for age, sex, and potential confounders (P for trend?=?0.004). Statistical significance did not change after further adjustment for total energy intake and BMI. There was no significant association between rs17782313 and obesity-related traits including BMI. Interactions between rs17782313 and sex, BMI, or total energy intake for triglyceride levels were not significant. To our knowledge, this study demonstrated for the first time that rs17782313 was associated with serum triglyceride levels in Asian population. Further studies are needed to confirm this result.