Serology based disease status of Pakistani population infected with Hepatitis B virus

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• 作者：Muhammad Masroor Alam (1)
  Soahil Zahoor Zaidi (2)
  Salman Akbar Malik (3)
  Asif Naeem (1)
  Shahzad Shaukat (1)
  Salmaan Sharif (1)
  Mehar Angez (1)
  Anis Khan (1)
  Javed Aslam Butt (4)
  
• 刊名：BMC Infectious Diseases
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：7
• 期：1
• 全文大小：473KB
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  20. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/7/64/prepub
  
• 作者单位：Muhammad Masroor Alam (1)
  Soahil Zahoor Zaidi (2)
  Salman Akbar Malik (3)
  Asif Naeem (1)
  Shahzad Shaukat (1)
  Salmaan Sharif (1)
  Mehar Angez (1)
  Anis Khan (1)
  Javed Aslam Butt (4)
  
  1. Department of Virology, National Institute of Health, Islamabad, Pakistan
  2. Head of Department of Virology, Principal Investigator-WHO Regional Reference Laboratory for Polio Eradication Initiative, National Institute of Health, Islamabad, Pakistan
  3. Head of Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
  4. Head of Department of Gastroenterology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
  

文摘

Background The infection rate of hepatitis B virus is continuously increasing in Pakistan. Therefore, a comprehensive study of epidemiological data is the need of time. Methods A total of 1300 individuals were screened for HBV infection markers including HBsAg, anti-HBsAg, HBeAg and anti-HBcAg. The association of these disease indicators was compared with patients' epidemiological characteristics like age, socio-economic status and residential area to analyze and find out the possible correlation among these variables and the patients disease status. Results 52 (4%) individuals were found positive for HBsAg with mean age 23.5 ± 3.7 years. 9.30%, 33.47% and 12% individuals had HBeAg, antibodies for HBsAg, and antibodies for HBcAg respectively. HBsAg seropositivity rate was significantly associated (p = 0.03) with the residing locality indicating high infection in rural areas. Antibodies titer against HBsAg decreased with the increasing age reflecting an inverse correlation. Conclusion Our results indicate high prevalence rate of Hepatitis B virus infection and nationwide vaccination campaigns along with public awareness and educational programs are needed to be practiced urgently.