Response of osteogenic sarcoma to neoadjuvant therapy: evaluated by 18F-FDG-PET
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- 作者：Zhaoming Ye (1)
Jiangjun Zhu (1)
Mei Tian (2) (3) (4)
Hong Zhang (2) (3) (4)
Hongwei Zhan (2) (3) (4)
Chunlei Zhao (2) (3) (4)
Disheng Yang (1)
Weixu Li (1)
Nong Lin (1) - 关键词：Chemotherapy ; Osteosarcoma ; Necrosis ; FDG ; PET
- 刊名：Annals of Nuclear Medicine
- 出版年：2008
- 出版时间：July 2008
- 年：2008
- 卷：22
- 期：6
- 页码：475-480
- 全文大小：322KB
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Jiangjun Zhu (1)
Mei Tian (2) (3) (4)
Hong Zhang (2) (3) (4)
Hongwei Zhan (2) (3) (4)
Chunlei Zhao (2) (3) (4)
Disheng Yang (1)
Weixu Li (1)
Nong Lin (1)
1. Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou, Zhejiang, 310009, China
2. Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
3. Zhejiang University Medical PET Center, Hangzhou, China
4. The Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China
文摘
Objective The aim of this study was to evaluate the potential role of F-18-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) in assessing the chemotherapy response of osteosarcoma when compared with histologically assessed tumor necrosis. Methods Fifteen patients were examined with whole-body FDG-PET prior to and following neoadjuvant therapy. The maximum standard uptake value (SUVmaxub>) of tumor and tumor to background ratio (TBR) prior to and following chemotherapy was used for semiquantitative PET imaging analysis. The SUVmaxub> of prechemotherapy and post-chemotherapy was recorded as SUV1ub> and SUV2ub>. TBR1ub> and TBR2ub> represented prechemotherapy and post-chemotherapy TBR. TBR was calculated by drawing an identical region of interest over the tumor and the contralateral normal limb or pelvis. Tumor necrosis was classified according to Salzer-Kuntschik’s criteria. Results Eight patients with more than 90% tumor necrosis were classified as showing good responses and seven patients with less than 90% tumor necrosis as showing poor responses. SUV2ub>/SUV1ub>, TBR2ub>/TBR1ub>, and TBR2ub> were significantly correlated with the tumor necrosis degree (P < 0.01, P < 0.001, P < 0.001). TBR2ub>/TBR1ub> were below 0.46 in all the patients with favorable responses, and higher than 0.49 in all the patients with unfavorable responses. However, it was difficult to distinguish good responses from poor responses by SUV2ub>/SUV1ub>. Conclusions FDG-PET is a promising tool to assess the chemotherapy response of osteosarcoma noninvasively. The TBR was better than SUVmaxub> in evaluating the chemotherapy response in this study.