The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage

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• 作者：Rupak Pathak ; Abdel Bachri ; Sanchita P. Ghosh ; Igor Koturbash…
• 刊名：Pharmaceutical Research
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：33
• 期：9
• 页码：2117-2125
• 全文大小：678 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Pharmacy
  Biochemistry
  Medical Law
  Biomedical Engineering
  
• 出版者：Springer Netherlands
• ISSN：1573-904X
• 卷排序：33

文摘

PurposeIonizing radiation (IR) generates reactive oxygen species (ROS), which cause DNA double-strand breaks (DSBs) that are responsible for cytogenetic alterations. Because antioxidants are potent ROS scavengers, we determined whether the vitamin E isoform γ-tocotrienol (GT3), a radio-protective multifunctional dietary antioxidant, can suppress IR-induced cytogenetic damage.