COX-2 modulates mammary tumor progression in response to collagen density

详细信息    查看全文

• 作者：Karla Esbona ; David Inman ; Sandeep Saha ; Justin Jeffery…
• 刊名：Breast Cancer Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：18
• 期：1
• 全文大小：4,135 KB
• 刊物主题：Cancer Research; Oncology;
• 出版者：BioMed Central
• ISSN：1465-5411

文摘

Background High breast density is linked to an increased risk of breast cancer, and correlates with changes in collagen. In a mouse model of mammary carcinoma in the context of increased collagen deposition, the MMTV-PyMT/Col1a1 tm1jae , there is accelerated mammary tumor formation and progression. Previous gene expression analysis suggests that increased collagen density elevates expression of PTGS2 (prostaglandin-endoperoxide synthase 2), the gene for cyclooxygenase-2 (COX-2).