Cerebellar Atrophy in Patients with Subcortical-Type Vascular Cognitive Impairment

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• 作者：Cindy W. Yoon (1)
  Sang Won Seo (1)
  Jun-Sung Park (2)
  Ki-Chang Kwak (2)
  Uicheul Yoon (3)
  Mee Kyung Suh (1)
  Geon Ha Kim (1)
  Ji Soo Shin (1)
  Chi Hun Kim (1)
  Young Noh (1)
  Hanna Cho (1)
  Min-Jeong Kim (4)
  Jong Hun Kim (5)
  Jee Hoon Roh (6)
  Jong-Min Lee (2)
  Duk L. Na (1)
  
• 关键词：White matter hyperintensities ; Lacunes ; Cerebellar atrophy ; Subcortical vascular MCI
• 刊名：The Cerebellum
• 出版年：2013
• 出版时间：February 2013
• 年：2013
• 卷：12
• 期：1
• 页码：35-42
• 全文大小：357KB
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• 作者单位：Cindy W. Yoon (1)
  Sang Won Seo (1)
  Jun-Sung Park (2)
  Ki-Chang Kwak (2)
  Uicheul Yoon (3)
  Mee Kyung Suh (1)
  Geon Ha Kim (1)
  Ji Soo Shin (1)
  Chi Hun Kim (1)
  Young Noh (1)
  Hanna Cho (1)
  Min-Jeong Kim (4)
  Jong Hun Kim (5)
  Jee Hoon Roh (6)
  Jong-Min Lee (2)
  Duk L. Na (1)
  
  1. Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, South Korea
  2. Department of Biomedical Engineering, Hanyang University, Seoul, South Korea
  3. Department of Biomedical Engineering, Catholic University of Daegu, Daegu, South Korea
  4. Department of Neurology, Seoul National University Boramae Hospital, Seoul, South Korea
  5. Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Goyang, South Korea
  6. Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
  
• ISSN：1473-4230

文摘

Recent studies suggest that the role of the cerebellum extends into cognitive regulation and that subcortical vascular dementia (SVaD) can result in cerebellar atrophy. However, there has been no evaluation of the cerebellar volume in the preclinical stage of SVaD. We aimed to compare cerebellar volume among patients with amnestic mild cognitive impairment (aMCI) and subcortical vascular mild cognitive impairment (svMCI) and evaluate which factors could have contributed to the cerebellar volume. Participants were composed of 355 patients with aMCI, svMCI, Alzheimer's disease (AD), and SVaD. Cerebellar volumes were measured using automated methods. A direct comparison of the cerebellar volume in SVaD and AD groups showed that the SVaD group had a statistically smaller cerebellar volume than the AD group. Additionally, the svMCI group had a smaller cerebellar volume than the aMCI group, with the number of lacunes (especially in the supratentorial regions) being associated with cerebellar volume. Cerebellar volumes were associated with some neuropsychological tests, digit span backward and ideomotor apraxia. These findings suggest that cerebellar atrophy may be useful in differentiating subtypes of dementia and the cerebellum plays a potential role in cognition.